Rajanyādi cūrṇa (RC) is an ayurvedic classical preparation used in the treatment of digestive disorders, fever, jaundice, anemia, and asthma. We seek to standardize this drug to ensure its quality. Objective: The current investigation was aimed at the preparation of cūrṇa in three batches so as to standardize it. Materials and Methods: The cūrṇa was prepared in-house in three different batches according to directions given in The Ayurvedic Formulary of India. The cūrṇa was evaluated based on organoleptic characters, physical characteristics, and physico-chemical parameters. High performance thin layer chromatography was carried out for the quantification of curcumin. Results: The parameters were found to be comparable and sufficient for the evaluation of the cūrṇa. Conclusion: Ayurvedic medicine, RC has been standardized using the various parameters and can be incorporated while developing the pharmacopoeial standards.

Background: Sitopaladi churna (SPC) is a popular polyherbal ayurvedic formulation used in the treatment of allergy and respiratory diseases. Objective: The present study was aimed to justify the classical use of antiallergic claim by performing the mast cell stabilizing activity of extracts of SPC. Materials and Methods: The protective effect of aqueous extract and methanolic extract - of SPC against compound 48/80-induced mast cell degranulation model was carried out. Results: Sitopaladi churna aqueous extract (SPCA) at the dose of 300 mg/kg and Sitopaladi churna methanolic extract (SPCM) at the doses of 150 and 300 mg/kg showed better protection of mast cell degranulation (65%-74%) and were comparable to the standard drug ketotifen (79%), when peritoneal mast cells were treated with compound 48/80. The protection against mast cell degranulation was significant (P < 0.0001). Conclusion: From the above results, it has been justified that SPC can be used to treat allergic disorders.

Background: Ayurvedic polyherbal formulations are widely prescribed for a wide range of infl ammatory conditions, yet, despite widespread use, there has been no systematic documentation of their safety and effi cacy. Objective: The present study was undertaken to evaluate the anti-infl ammatory activity of aqueous extracts of Ajmodadi churna (AJM) in rats. Materials and Methods: Carrageenan-induced hind paw edema and air pouch infl ammation models were used for the study. Results: The extracts showed signifi cant antiinfl ammatory activity, reducing paw edema volume by 0.417 ± 0.097 and 0.379 ± 0.049, respectively. In the carrageenan-induced air pouch model, AJM reduced total leukocyte count by 73.09 ± 7.13 and 62.17 ± 10.53, granulocyte count by 69.48 ± 5.44 and 63.33 ± 4.13, and myeloperoxidase activity by 14.84 ± 0.91 and 18.44 ± 3.18, respectively, compared to controls. Discussion and Conclusion: AJM signifi cantly reduced paw edema, during the second phase of edema development. In the carrageenan-induced air pouch model, AJM inhibited cellular infi ltration into the air pouch fl uid. We conclude that AJM is an effective candidate for prevention or treatment of acute infl ammation

Introduction: “Sitopaladi churna” is a reputed Ayurvedic polyherbal medicine prescribed for pleurodynia, intercostal neuralgia, cough associated with bronchitis, supportive agent for allergy, viral respiratory infection, and in pharyngeal and chest congestion. Antioxidants play an important role in protecting cellular damage by reactive oxygen species. Plants containing phenolic compounds have been reported to possess strong antioxidant properties. Methods: Antioxidant potential of the Sitopaladi churna was studied using different in vitro free radical models like DPPH, ABTS, nitric oxide and superoxide scavenging radical models. Results: The extracts showed good dose dependent free radical scavenging property in all the models. IC50 values of methanolic and aqueous extracts of Sitopaladi churna were found to be 65.6 and 44.88 μg/ml for DPPH, 74.5 and 66.46 μg/ml for ABTS, 191.77 and 170.15 μg/ml for nitric oxide, 94.79 and 62.03 μg/ml for superoxide radical, respectively. Total phenolic contents of aqueous and methanolic extract were found to be 256.25 and 298.2 μg equivalent of gallic acid. Conclusions: The antioxidant potential may be directly linked to the phenolic compounds present in the ingredients of Sitopaladi churna. The data obtained in this study suggest a possible use of Sitopaladi churna as a natural antioxidant agent.

Background: Floating tablets prolong the gastric residence time of drugs, improve bioavailability, and facilitate local drug delivery to the stomach. With this objective, floating tablets containing aqueous extract of liquorice as drug was prepared for the treatment of Helicobacter pylori and gastric ulcers. Methods: The aqueous extract of liquorice was standardized by HPTLC. Tablets containing HPMC K100M (hydrophilic polymer), liquorice extract, sodium bicarbonate (gas generating agent), talc, and magnesium stearate were prepared using direct compression method. The formulations were evaluated for physical parameters like diameter, thickness, hardness, friability, uniformity of weight, drug content, buoyancy time, dissolution, and drug release mechanism. The formulations were optimized on the basis of buoyancy time and in vitro drug release. Results: The diameter of all formulations was in the range 11.166–11.933 mm; thickness was in the range 4.02–4.086 mm. The hardness ranged from 3.1 to 3.5 kg/cm2. All formulations passed the USP requirements for friability and uniformity of weight. The buoyancy time of all tablet formulations was less than 5 min and tablet remained in floating condition throughout the study. All the tablet formulations followed zero-order kinetics and Korsemeyer–Peppas model in drug release. Conclusion: The optimized formulation was found to be F6 which released 98.3% of drug in 8 h in vitro, while the buoyancy time was 3.5 min. Formulations containing psyllium husk, sodium bicarbonate and HPMC K100M in combination can be a promising for gastroretentive drug delivery systems.

2011 ,MPharm Part II. The In-house Sitopaladi churna was prepared and studied for various physic-chemical parameters in comparison with the marketed samples. Antioxidant activity of extracts (aqueous and methanolic) was studied in different in vitro models. The mast cell stabilising potential of churna extracts was shown in Compound 48/80 induced model in rats.

2011,MPharm Part II. Curcumin ethosomes and liposomes were prepared and characterised using various parameters including the ex vivo skin permeation and partition coefficient studies.

2010 , MPharm Part II. In-house Ajmodadi churna was formulated as per AFI and compared with one marketed sample for various physic-chemical parameters. The etracts (aqueous and methanolic) showed free radical scavenging activity in the tested in vitro models. Aqueous extract showed anti-inflammatory activity in rat models.

2010, MPharm Part II. The Pharmacognostic studies provide valuable information regarding the identification and authentication of for Ficus species such as F. religiosa, F. glomerata, F. retusa and F. carica.