MD Biochemistry | Department of Biochemistry

Department of Biochemistry KMC Manipal

About the Department

The department of Biochemistry was established in the year 1968, following the founding of Kasturba Medical College, Manipal, in 1953. The department educates medical students at the undergraduate level. It also provides MD and MSc in Medical Biochemistry postgraduate programs. The department also conducts regular CMEs for its postgraduate students and faculty. The diagnostic lab at the Biochemistry department is managed by a group of experienced and talented faculty involved in teaching and research. The diagnostic laboratory provides services to over 4000 outpatients and inpatients per day.

This lab is NABL accredited and caters to all patients visiting our hospital, and acts as a referral laboratory for private hospitals and physicians practicing in the surrounding areas. The lab has two specialty areas: a center of excellence for inborn error of metabolism screening and analytical toxicology, both of which were established in 2012 and 2015. Approximately two lakh thirty thousand tests are handled by the laboratory every month. The laboratory is committed to maintaining the highest quality of performance using the latest technology and equipment to provide rapid and reliable results for the patient in the shortest turnaround time.

Faculty and postgraduate students are encouraged to do research and publish scientific papers. In 2020-21, the faculty contributed 28 publications in International and National Scopus indexed journals. Many Biochemistry faculty members have written articles in various newspapers published by the local media presented in many television/radio programs aired by local channels.

The Biochemistry department and the other lab departments are interconnected to the hospital by a Laboratory Information System (LIS) for speedier and accurate reports. Samples are bar-coded and fed into the equipment, automatically performing the tests indicated by the bar code. The test results obtained are instantly interphases online to the doctor's desk after verification eliminating transcriptional errors.

Adjunct faculty

We have adjunct faculty at the national & international level from different specialty areas, including research and industry. Regular online interactions are conducted with our adjunct faculty, helpful to our students to get insight into their field.

Dr. Barnali Das MD

Consultant Laboratory Medicine,

Kokilaben Dhirubhai Ambani Hospital & Medical Research Institute,Mumbai, Maharashtra

Dr. Anibh M Das, MD., PhD

Professor Paediatric Nephrology, Hepatology and Metabolic Disorders Hannover Medical School, Hannover

Dr. Shilpy Sharma

Ph.D. UGC-Assistant

Professor Department of Biotechnology,

Savitribai Phule,Pune

Dr. Sandeep Sewlikar

ROCHE Diagnostics, Pvt Ltd.

Mumbai, India

Dr. Annayya Rao Aroor

MBBS, MD, PhD, MNAMS, FACBI,DABCC FAACC

University of Missouri, School of Medicine,

Columbia, MO

Series of guest lecture on Inborn Errors of Metabolism by Dr. Anibh Martin Das on 17^th & 18^th September 2019.

Talk on Enigma behind Thyroid Function Tests- Standardization Efforts by Dr.Barnali Das at ACBICON 2018.

Alumni

Dr. Krishna Sharma, Ph.D.,

Professor of Ophthalmology and Biochemistry, serves as the director of research for the department of ophthalmology, University of Missouri-Columbia, USA.

Dr. Vishukumar Aimanianda

Directeur de recherche, Molecular Mycology Unit, Department of Mycology, Institut Pasteur, 75015 Paris, France

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PhD

The Department of Biochemistry offers regular Ph.D. for the eligible candidates. Since 1979 sixty candidates have been successfully awarded doctorate degree, and the department currently has five recognized Ph. D. guides and four registered students. MAHE also offers fellowships to excellent candidates. For more information on Ph.D. with us, please click here (please show this link https://manipal.edu/mu/academics/phd.html )

PhD Ongoing

Name	Full time/Part-time
Monalisa Biswas	Full time
Sairoz	Part-time
Samreen M Sheik	Part-time
Anupama	Part-time

Awarded

Sl No	Name	Year
1	Dr. (Mrs.). S. Sumathi	1979
2	Dr.B Ramakrishna Nayak	1980
3	Dr. P Gopalakrishna Bhat	1981
4	Dr. B Shivaraj	1981
5	Dr. A Ramesh Bhat	1982
6	Dr. K Krishna Sharma	1982
7	Dr. G Chandrashekar	1983
8	Dr. K Sudhakar Prabhu	1984
9	Dr. A . R. Aroor	1984
10	Dr. K Rambabu	1984
11	Dr. S. L Udupa	1985
12	Dr. Raju Thomas Jacob	1986
13	Dr. R. H Nagaraj	1987
14	Dr. A. V. Moideen Kutty	1988
15	Dr. N. Mallikarjuna Rao	1988
16	Dr. S. Swaminathan	1988
17	Dr. S. Sujatha	1988
18	Dr.(Mrs.) K. Beena Rai	1988
19	Dr. Anuradha Kumar	1989
20	Dr. (Ms.) Poornima Kamath	1990
21	Dr. (Mrs.) Pragna Rao	1991
22	Dr. Nagaraja Kumari	1991
23	Dr. (Mrs.) Gladys D’Souza	1991
24	Dr. (Mrs.) Maya Roche	1991
25	Dr. (Ms.) Vidya Prabhu	1993
26	Dr. (Mrs.) Malathi Kumudam	1993
27	Dr. (Mrs.) Manjula Shantaram	1993
28	Dr. H. Rajendra Kedlaya	1995
29	Dr. R. Senthil Kumar	1995
30	Dr. H. Madhukar Mallya	1997
31	Dr. Shivananda Nayak B	1997
32	Dr. (Mrs.) Shaila H. P	1998
33	Dr. (Mrs.) Gayathri M Rao	1999
34	Dr. (Mrs.) Sudha K	1999
35	Dr. Raghothama C	1999
36	Dr. Sulochana Devi	1999
37	Dr. Usha Kumari	1999
38	Dr. (Mrs.) Nandini H. K	2000
39	Dr. Vijayalakshmi Varma P. R	2000
40	Dr. Padmanabha udupa E.G	2001
41	Dr. Jagadish Ulloor N	2002
42	Dr. Shivarajashankar Y.M	2002
43	Dr. Shivashankara A.R	2002
44	Dr. Geetha Samak	2003
45	Dr. B Shivananda Baliga	2003
46	Dr. Shobha U Kamath	2003
47	Dr. Winston Costa Pereira	2003
48	Dr. Niveditha L Rao	2003
49	Dr. Guruprasad Rao	2005
50	Dr. Surekha Bhat	2005
51	Dr. Chandrika D Nayak	2005
52	Dr. Somashekar Shetty	2005
53	Dr. Revathi P Shenoy	2006
54	Dr. Vinutha R Bhat	2014
55	Dr. Yousef Rezaei Chianeh	2016
56	Dr. Jenu Maria Thomas	2017
57	Dr. Bhaskar Gaokar	2017
58	Dr. Azadeh Bagheri	2018
59	Dr. Ranjini H. S	2019
60	Dr. Prajna P Shetty	2021

Services Offered

24 X 7 Diagnostic Lab

The biochemistry department has a 24 X 7 fully air-conditioned diagnostic lab with high-end auto analyzers, which generates 10,000 lab reports per day for all the outpatients and inpatients visiting our hospital. A total of 27 lab technicians are working in 3 shifts to provide these services. In addition to routine chemistry tests, specialized tests include therapeutic drug monitoring, hormones, and a first-trimester screening panel. The Turn Around Time (TAT) for the tests is a maximum of 6 hours in working hours and non-working hours is 8 hours. The department has facilities to do all tests required for emergency management and routine care of patients within its premises. None of the emergency tests are outsourced.

Metabolic Screening Lab

Due to a lack of investigative capabilities and financial constraints, a considerable proportion of inborn errors of metabolism (IEM) problems in children go undiagnosed in India. Lack of awareness about these IEM disorders in this region of south India has motivated us to start the IEM laboratory. The only IEM lab in this district's IEM lab, serving a population of around 50,00,000 people. Patients from Kerala, Karnataka, and Andhra Pradesh. Since its inception, it has generated more than 4000 reports. Dried blood spot (DBS) samples collected from newborn babies are screened for seven congenital disorders, including Congenital Adrenal Hyperplasia (CAH), Congenital Hypothyroidism, Maple Syrup Urine Disease (MSUD), Phenylketonuria (PKU), Glucose-6-phosphate dehydrogenase deficiency (G6PD), Biotidinase deficiency, and Galactosemia, under the Newborn Screening program. The other investigations carried out in the IEM lab are amino acid and vitamins quantitative estimation using HPLC analyzer. Quantitative estimations of amino acids and vitamins are done using an HPLC analyzer.

Analytical Toxicology Lab

Kasturba Medical College is an important tertiary referral hospital serving 130,000,000 people in Karnataka, Kerala, and Andhra Pradesh. In order to support diagnosis, early intervention, and comprehensive care, the Analytical toxicology wing was started. This wing was established in collaboration with the Department of Biochemistry, Forensic Medicine, and Pharmacy Practice. This center offers a different panel of tests, including- drug abuse panel, pesticide panel; alcohol panel; narcotic panel, and heavy metal panel. Since its inception, it has generated more than 5000 reports.

Research

As biochemistry is a core basic science department offering diagnostic services and supporting postgraduate and PhD programs, it regularly conducts academic activities like CMEs and conferences. It has good research output in the form of publications.

Grants Sanctioned

Sl No	Project Title	Sponsor	Duration & sanctioned amount
1	To establish a newborn screening lab and to initiate the mass screening program to reduce the mortality and morbidity of newborn children	Vision Group on Science and Technology, Bangalore	2015-2018 Rs. 60 lakhs
2	Stars in Global Health: To study the need and viability of a newborn screening program in India	Grand Challenges Canada	2017-2018 $ 1,00,000 CAD
3	Establishment of the thyroid reference range for the Indian population	Roche Diagnostics	2017-2020 Rs. 50 lakhs
4	Estimation of pesticide levels in farmers of Karnataka	Government of Karnataka	2017-2021 Rs. 33 lakhs
5	Role of placental monocarboxylate transporter 8(MCT 8) expression on adverse pregnancy outcomes in Indian population	ICMR Grant	2021 – 2023 Rs. 25 lakhs

List of Publications

Sl No	Title	Authors
1	Diagnostic performance of C-reactive protein level and its role as a potential biomarker of severe dengue in adults (Q1 Journal)	Raghavendra Rao, Snehal Nayak, Akhilesh K Pandey, Shobha U Kamath *
2	Lifestyle Modification with Physical Activity Promotion on Leptin Resistance and Quality of Life in Metabolic Syndrome - A Systematic Review with Meta-Analysis (Q2 Journal)	Parameshwar Anche , Arun G. Maiya, Shobha Ullas Kamath, B Ananthakrishna Shastry Ravishankar
3	Effect of Green, Tulsi, and Areca Teas on the Color Stability of Two Composite Resin Materials – an in vitro Spectrophotometric Analysis (Q2 Journal)	Akshata Patil, Vidya-Saraswathi Muliya, Kalyana-Chakravarthy Pentapati, Shobha Kamath
4	Effect of photobiomodulation therapy on inflammatory cytokines in healing dynamics of diabetic wounds: a systematic review of preclinical studies (Q2 Journal)	Gagana Karkada , G. Arun Maiya , Nicolette N. Houreld , Praveen Arany , Mohandas Rao KG , Shalini Adiga , Shobha Ullas Kamath & Somashekar Shetty
5	Plasma levels of angiogenic and angiostatic factors after panretinal photocoagulation for proliferative diabetic retinopathy (Q2 Journal)	Bhaskar Gaonkar, Krishnananda Prabhu, Pragna Rao, Asha Kamat, Krishna Rao, Muralidhar Varma

Patents and Copywrite received

1	Received copyright certificate for "Noninvasive tests for Diabetes Mellitus" Registration Number: CF- 4826/2021- short educational video - Copyright Office Govt Of India – 11/02/2020 – 216/2020- CO/CF
2	Received copyright certificate for “Post Analytical Sample Archival System” Diary No: 11940/2015- CO/L – registered on 03/04/2018 [Ref – BNP/CR/18 dated 9th August 2018; R.K Dewan & Co]
3	“System and method for locating and enabling retrieval of containers from a tray” has been filed at the Indian Patent Office on 05th July 2019 as a complete application. Application no. Accorded to the same is 201941027085.
4	“System, medical device and method for diagnosing medical conditions of a patient” has been filed at the Indian Patent Office on 24th August 2019 as a complete application. Application no. Accorded to the same is 201941034195.
5	“A biochemical detection strip and a method to detect an analyte” has been filed at the Indian Patent Office on 15th January 2020 as a complete application. Application no. Accorded to the same is 202041001862.
6	Received copyright for “Communication skill – Biochemistry Perceptive” Registration Number: CF-4655/2020 – Short educational video - Copyright Office Govt Of India – 14/09/2020 - 2608/2020-CO/CF
7	Received copyright for Noninvasive tests for Diabetes mellitus: Registration Number: CF-4826/2021 – Short educational video - Copyright Office Govt Of India – 11/03/2021 - 2616/2020-CO/CF