Dr Mahadev Rao

Dr Mahadev Rao

Professor & Head

Department of Pharmacy Practice

My Name is Dr Mahadev Rao, my profilePage is. I am aProfessor & Headin .
  • CURRENT ACADEMIC ROLE & RESPONSIBILITIES

    Mahadev Rao, Professor and Head at Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, joined Manipal Academy of Higher Education on April 04, 2017. Dr. Rao completed his PhD in pharmaceutical sciences at Manipal College of Pharmaceutical Sciences, studying free radical-induced nephrotoxicity of cisplatin and its protection by selenium compounds. His PhD research work won him the Simon Wolf Charitable Foundation award (Cambridge, UK) in 1998. Determined to pursue a career in research, Mahadev moved to National Cancer Institute, NIH, Bethesda, MD as a Fogarty International Postdoctoral Fellow where he worked for two years in basic cancer genetics. In 2003, Dr Rao moved to Lombardi Cancer Center, Georgetown University to purse signal transduction mechanisms of cyclins in breast and prostate cancer. In 2006, Dr. Rao joined Surgery/thoracic gastro-intestinal branch at NCI where he rose from a position of Postdoctoral Scientist to that of a Staff Scientist at National Cancer Institute. Dr. Rao has worked extensively on basic, translational and clinical research at NCI. His major expertise include repurposing  old antitumor agents, personalized medicine in thoracic cancers (lung, malignant pleural mesothelioma, esophageal and gastric), genetic mechanisms for tobacco mediated cancers, induction of cancer testis antigens in thoracic cancer by epigenetic drugs for adoptive immunotherapy and the metabolome. Dr. Rao has numerous papers in peer reviewed journals such as Nature, Nature immunology, Cancer Research, Clinical Cancer Research, Journal of immunology, Journal of immunotherapy, Molecular Cell, MCB, JBC, PNAS, Cell metabolism, Cell cycle etc. 

    He teaches undergraduate and postgraduate students; and guide doctoral students.

    He:

    • Approved PhD guide (Field:Cancer) in Manipal Academy of Higher Education.
    • Supervises the department's daily activities.
    • Mentors student's disserations and projects.
    • Plans and conducts clinical pharmacy workshops and training programs.
    • Establishes research collaborations at national and international levels.
    • Member of Pharmacy and Therapeutic committee of Kasturba Hospital, Manipal.
    • Heads research committee of the department.
  • SUBJECTS CURRENTLY TEACHING
    Subject
    :
    Pharmacotherapeutics-III
    Subject code
    :
    PPR 4.1 T
    Year / Semester
    :
    Fourth Year Pharm.D
    Subject
    :
    Pharmacotherapeutics- I & II
    Subject code
    :
    PPR 4.7 T
    Year / Semester
    :
    First Year Pharm.D (PB)
    Subject
    :
    Clinical Research
    Subject code
    :
    PPR 5.1 T
    Year / Semester
    :
    Fifth Year Pharm.D
    Subject
    :
    Pharmacotherapeutics-I
    Subject code
    :
    MPP 102 T
    Year / Semester
    :
    First Semester M.Pharm
    Subject
    :
    Clinical Research
    Subject code
    :
    MPP 104 T
    Year / Semester
    :
    First Semester M.Pharm
    Subject
    :
    Pharmacotherapeutics-II
    Subject code
    :
    MPP 202 T
    Year / Semester
    :
    Second Semester M.Pharm
  • ACADEMIC QUALIFICATIONS
    Degree
    :
    PhD (Doctor of Philosophy)
    Specialisation
    :
    Pharmaceutical Sciences
    Institute
    :
    Manipal College of Pharmaceutical Sciences / Mangalore University
    Year of passing
    :
    2000
    Degree
    :
    MPharm (Master of Pharmacy)
    Specialisation
    :
    Pharmacology
    Institute
    :
    Government College of Pharmacy, Bangalore University, Bangalore
    Year of passing
    :
    1995
    Degree
    :
    BPharm (Bachelor of Pharmacy)
    Specialisation
    :
    Pharmacy
    Institute
    :
    NGSM Institute of Pharmaceutical Sciences, Mangalore University, Mangalore
    Year of passing
    :
    1992
    Degree
    :
    DPharm (Diploma of Pharmacy)
    Specialisation
    :
    Pharmacy
    Institute
    :
    SSS College of Pharmacy, Kadandale
    Year of passing
    :
    1986
  • EXPERIENCE
    Institution / Organisation
    :
    Surgery/Thoracic and GI Oncology Branch, NCI/NIH, Bethesda, MD
    Designation
    :
    Staff Scientist
    Role:Research
    Tenure
    :
    2012-2016
    Institution / Organisation
    :
    Surgery Branch, NCI/NIH, Bethesda, MD
    Designation
    :
    Research fellow
    Role:Research
    Tenure
    :
    2007-2012
    Institution / Organisation
    :
    Department of Oncology, Georgetown University, Washington DC
    Designation
    :
    Postdoc Fellow
    Role:Research
    Tenure
    :
    2003-2007
    Institution / Organisation
    :
    Division of Basic Sciences, NIH, Bethesda, MD
    Designation
    :
    Forgaty International Postdoc Fellow
    Role:Research
    Tenure
    :
    2000-2002
    Institution / Organisation
    :
    NGSM Institute of Pharmaceutical Sciences, Mangalore, India
    Designation
    :
    Assistant Professor & Head, Dept. of Pharmacology
    Role:Teaching UG and PG students and Research
    Tenure
    :
    1999-2000
  • CURRENT ACADEMIC ROLE & RESPONSIBILITIES

    Mahadev Rao, Professor and Head at Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, joined Manipal Academy of Higher Education on April 04, 2017. Dr. Rao completed his PhD in pharmaceutical sciences at Manipal College of Pharmaceutical Sciences, studying free radical-induced nephrotoxicity of cisplatin and its protection by selenium compounds. His PhD research work won him the Simon Wolf Charitable Foundation award (Cambridge, UK) in 1998. Determined to pursue a career in research, Mahadev moved to National Cancer Institute, NIH, Bethesda, MD as a Fogarty International Postdoctoral Fellow where he worked for two years in basic cancer genetics. In 2003, Dr Rao moved to Lombardi Cancer Center, Georgetown University to purse signal transduction mechanisms of cyclins in breast and prostate cancer. In 2006, Dr. Rao joined Surgery/thoracic gastro-intestinal branch at NCI where he rose from a position of Postdoctoral Scientist to that of a Staff Scientist at National Cancer Institute. Dr. Rao has worked extensively on basic, translational and clinical research at NCI. His major expertise include repurposing  old antitumor agents, personalized medicine in thoracic cancers (lung, malignant pleural mesothelioma, esophageal and gastric), genetic mechanisms for tobacco mediated cancers, induction of cancer testis antigens in thoracic cancer by epigenetic drugs for adoptive immunotherapy and the metabolome. Dr. Rao has numerous papers in peer reviewed journals such as Nature, Nature immunology, Cancer Research, Clinical Cancer Research, Journal of immunology, Journal of immunotherapy, Molecular Cell, MCB, JBC, PNAS, Cell metabolism, Cell cycle etc. 

    He teaches undergraduate and postgraduate students; and guide doctoral students.

    He:

    • Approved PhD guide (Field:Cancer) in Manipal Academy of Higher Education.
    • Supervises the department's daily activities.
    • Mentors student's disserations and projects.
    • Plans and conducts clinical pharmacy workshops and training programs.
    • Establishes research collaborations at national and international levels.
    • Member of Pharmacy and Therapeutic committee of Kasturba Hospital, Manipal.
    • Heads research committee of the department.
  • SUBJECTS CURRENTLY TEACHING
    Subject Subject code Year / Semester
    Pharmacotherapeutics-III PPR 4.1 T Fourth Year Pharm.D
    Pharmacotherapeutics- I & II PPR 4.7 T First Year Pharm.D (PB)
    Clinical Research PPR 5.1 T Fifth Year Pharm.D
    Pharmacotherapeutics-I MPP 102 T First Semester M.Pharm
    Clinical Research MPP 104 T First Semester M.Pharm
    Pharmacotherapeutics-II MPP 202 T Second Semester M.Pharm
  • ACADEMIC QUALIFICATIONS
    Degree Specialisation Institute Year of passing
    PhD (Doctor of Philosophy) Pharmaceutical Sciences Manipal College of Pharmaceutical Sciences / Mangalore University 2000
    MPharm (Master of Pharmacy) Pharmacology Government College of Pharmacy, Bangalore University, Bangalore 1995
    BPharm (Bachelor of Pharmacy) Pharmacy NGSM Institute of Pharmaceutical Sciences, Mangalore University, Mangalore 1992
    DPharm (Diploma of Pharmacy) Pharmacy SSS College of Pharmacy, Kadandale 1986
  • EXPERIENCE
    Institution / Organisation Designation Role Tenure
    Surgery/Thoracic and GI Oncology Branch, NCI/NIH, Bethesda, MD Staff Scientist Research 2012-2016
    Surgery Branch, NCI/NIH, Bethesda, MD Research fellow Research 2007-2012
    Department of Oncology, Georgetown University, Washington DC Postdoc Fellow Research 2003-2007
    Division of Basic Sciences, NIH, Bethesda, MD Forgaty International Postdoc Fellow Research 2000-2002
    NGSM Institute of Pharmaceutical Sciences, Mangalore, India Assistant Professor & Head, Dept. of Pharmacology Teaching UG and PG students and Research 1999-2000
  • AREAS OF INTEREST, EXPERTISE AND RESEARCH
    Areas of interest
    :
    Developing tumor tissue collection bank from various histologies as well as will generate in-house tumor cell lines and eventually those tumor samples will be subjected to exome or transcriptome profiling. Generation of this genomic databank at Manipal University will be used for intramural as well as extramural prospective studies, basic, translational and clinical research. Also Dr Rao would like to establish the repurposing old anticancer drugs as well as to establish the personalized treatment of cancers based on genetic makeup in Manipal University.
    Areas of expertise
    :
    Repurposing old antitumor agents, personalized medicine in thoracic cancers (lung, malignant pleural mesothelioma, esophageal and gastric), genetic mechanisms for tobacco mediated cancers, induction of cancer testis antigens in thoracic cancer by epigenetic drugs for adoptive immunotherapy and the metabolome. Dr. Rao had involved in several preclinical and FDA approved clinical trials in repurposing the old drugs and in personalized lung cancer and mesothelioma patients.
    Areas of research
    :
    Discovery and development of anti-cancer drugs that exploit our knowledge of the cancer genome and cancer biology. His passion is personalized medicine and repurposing of old drugs.
  • PROFESSIONAL AFFILIATIONS AND CONTRIBUTIONS
    • Member of American Association for Cancer Research
    • Member of Registered Pharmacist, Karnataka State Pharmacy Council
    • Life Member of Indian Pharmaceutical Association
     
    HONORS/AWARDS:
     
    • Department of Human & Health Services best employee performance award from 2008-2015
    • Fogarty International postdoctoral fellowship award at NIH (2000-2002)
    • Simon Wolf Charitable foundation award (Cambridge, UK) for contribution in Free Radical Biology
    • Senior Research Fellowship for Ph.D. from Department of Atomic Energy, India
    • Junior Research Fellowship for M.Pharm. from University Grants Commission, India
     
    COLLABORATIONS:
     
    • Dr. Narayanan Rajendran, University of Kentucky, USA
    • Dr. Ganesha Rai Bantukallu, NCATS, NIH, Shadygrove, USA
    • Dr. Vivek Shukla, TGBI, NCI, NIH, Bethesda, USA
    •  

    OTHER ASSOCIATIONS:

    • Member of Pharmacy and Therapeutic Committee of Kasturba Hospital, Manipal
     
     
  • AREAS OF INTEREST, EXPERTISE AND RESEARCH
    Areas of interest Developing tumor tissue collection bank from various histologies as well as will generate in-house tumor cell lines and eventually those tumor samples will be subjected to exome or transcriptome profiling. Generation of this genomic databank at Manipal University will be used for intramural as well as extramural prospective studies, basic, translational and clinical research. Also Dr Rao would like to establish the repurposing old anticancer drugs as well as to establish the personalized treatment of cancers based on genetic makeup in Manipal University.
    Areas of expertise Repurposing old antitumor agents, personalized medicine in thoracic cancers (lung, malignant pleural mesothelioma, esophageal and gastric), genetic mechanisms for tobacco mediated cancers, induction of cancer testis antigens in thoracic cancer by epigenetic drugs for adoptive immunotherapy and the metabolome. Dr. Rao had involved in several preclinical and FDA approved clinical trials in repurposing the old drugs and in personalized lung cancer and mesothelioma patients.
    Areas of research Discovery and development of anti-cancer drugs that exploit our knowledge of the cancer genome and cancer biology. His passion is personalized medicine and repurposing of old drugs.
  • PROFESSIONAL AFFILIATIONS AND CONTRIBUTIONS
    • Member of American Association for Cancer Research
    • Member of Registered Pharmacist, Karnataka State Pharmacy Council
    • Life Member of Indian Pharmaceutical Association
     
    HONORS/AWARDS:
     
    • Department of Human & Health Services best employee performance award from 2008-2015
    • Fogarty International postdoctoral fellowship award at NIH (2000-2002)
    • Simon Wolf Charitable foundation award (Cambridge, UK) for contribution in Free Radical Biology
    • Senior Research Fellowship for Ph.D. from Department of Atomic Energy, India
    • Junior Research Fellowship for M.Pharm. from University Grants Commission, India
     
    COLLABORATIONS:
     
    • Dr. Narayanan Rajendran, University of Kentucky, USA
    • Dr. Ganesha Rai Bantukallu, NCATS, NIH, Shadygrove, USA
    • Dr. Vivek Shukla, TGBI, NCI, NIH, Bethesda, USA
    •  

    OTHER ASSOCIATIONS:

    • Member of Pharmacy and Therapeutic Committee of Kasturba Hospital, Manipal