Dr. D Anandh
Professor
Manipal Institute of Regenerative Medicine
Qualification: PhD
CURRENT ACADEMIC ROLE & RESPONSIBILITIES
Associate Professor in Manipal Institute of Regenerative Medicine
SUBJECTS CURRENTLY TEACHING
| Subject | Semester / Year |
|---|---|
| Hematopoietic stem cell | Second Semester |
| Hematopoiesis | Second Semester |
| Neurodegenerative Diseases: Multiple Sclerosis | Third Semester |
| Stem Cell and Restoration of Vision | Third Semester |
| Homing of Stem Cell | Third Semester |
| Tissue Engineering | Third Semester |
| BIOMOLECULES | First Semester |
| BIOMOLECULES | First Semester |
| BIOMOLECULES | First Semester |
| LABORATORY METHODOLOGIES | First Semester |
| LABORATORY METHODOLOGIES | First Semester |
| LABORATORY METHODOLOGIES | First Semester |
| LABORATORY METHODOLOGIES | First Semester |
| EMBRYONIC DEVELOPMENT | Second Semester |
| ARCHITECTURE OF CELLS, TISSUE AND ORGANS | Second Semester |
ACADEMIC QUALIFICATIONS
| Degree | Specialisation | Institute | Year of passing |
|---|---|---|---|
| PhD | Neurophysiology | National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka. | 2005 |
| MPhil | Neurophysiology | National Institute of Mental Health and Neurosciences,Bengaluru, Karnataka | 2001 |
| MSc | Biochemistry | Bharathidasan University | 1999 |
| BSc | Biochemistry | Bharathidasan University | 1997 |
Experience
| Institution / Organisation | Designation | Role | Tenure |
|---|---|---|---|
| Manipal Institute of Regenerative Medicine, Bengaluru | Professor | Teaching, Research | 2012 - till Present |
| Manipal Institute of Regenerative Medicine | Associate Professor | Teaching, Research | 2015-2022 |
| Manipal Institute of Regenerative Medicine | Assistant Professor | Teaching, Research | 2012-2015 |
| University of Tennessee Health Science Center, USA | Research Associate | Research | 2007-2010 |
| Duke University | Post-Doctoral Fellow | Research | 2006-2007 |
| Otto-von-Guerick University, Germany | Post-Doctoral Fellow | Research | 2004-2005 |
Research Focus: Our research focus on the potential of extracellular vesicles, particularly exosomes derived dental pulp stem cells (DPSCs) as a promising therapeutic agent for treating hippocampal neurodegenerative diseases like Alzheimer’s disease and temporal lobe epilepsy (TLE). We have reported the neuro-immunomodulatory, neuroprotective, neurogenic and disease modifying potential of DPSCs/DPSC-Secretome/DPSCs exosome in in vitro and in vivo models of hippocampal neurodegeneration. DPSC-based therapies hold promise for treating Alzheimer’s disease, TLE, and possibly other neurodegenerative conditions characterized by hippocampal dysfunction. Currently we are exploring the precise mechanisms through which DPSCs and its exosomes exert their neuroprotective, neurogenic effects which could lead to the development of more targeted therapies.
AREAS OF INTEREST, EXPERTISE AND RESEARCH
Area of Interest
Neurodegenerative Diseases, Temporal Lobe Epilepsy, Parkinson’s Disease, Stem Cell therapies, Cognition.
Area of Expertise
Stem cell therapies for Temporal Lobe Epilepsy, Parkinson’s Disease & Alzheimer’s disease.
Area of Research
Neurodegenerative diseases are devastating diseases wherein there is no identifiable treatment available so far. The primary focus of our research group is to understand the molecular, biochemical and cytoarchitectural changes that lead to progressive neurodegeneration and behavioural impairments in temporal lobe epilepsy, Parkinson’s disease and Alzheimer’s disease. From neuroprotection perspectives, we are actively exploring the possibilities of stimulating endogenous stem cells for functional recovery by means of environment manipulation, novel drug treatments and stem cell therapy. In line with this, we have demonstrated that a single intramuscular injection of genetically modified erythropoietin can protect dopaminergic neurons in animal models of Parkinson’s disease. We have also reported that transplanting hippocampal cells in brain injured rats can prevent neurodegeneration and improves cognitive functions. Currently, we are involved in understanding the molecular mechanisms of neuroprotection conferred by transplanted cells in protecting hippocampal neurons and ameliorating cognitive co-morbidities that are commonly observed in temporal lobe epilepsy, Parkinson’s disease and Alzheimer’s disease.
Professional Affiliations & Contributions
- Research Associate, University of Tennessee Health Science Center, USA
- Post Doctoral Fellowship, Duke University, USA
- Post Doctroal Fellowship, Otto-von-Guerick University, Germany
- Summer Fellow, RIKIN Brain Science Institute, Japan
- National Institute of Mental Health and Neurosciences Fellowship, 1999-2004
- Gold Medal, M.Phil. Neurophysiology, NIMHANS, Bangalore, 1999-2001
- Winner of R.N.Murthy award, NIMHANS, Bangalore
- Best Poster Award for Poster Presentation Golden APPICON 2004
Cytotherapy
2014-01-07 Scientific R R Bhonde Chaitra Venugopal B K Pradeep Kumar T N Sathyaprabha
Infusion of Human Embryonic Kidney Cell Line Conditioned Medium Reverses Kainic Acid Induced Hippocampal Damage in Mice
Journal of Clinical and Biomedical Sciences
2014-01-06 Scientific Chaitra Venugopal Shashank Chandanala Harishchandra Prasad YS
Stem Cells Based Therapy For Temporal Lobe Epilepsy.
Genes,Brain and Behavior
2014-01-06 Scientific Flanigan TJ Xue Y Kishan Rao Michael P McDonald
Abnormal vibrissa-related behavior and loss of barrel field inhibitory neurons in 5xFAD transgenics.
Genes, Brain and Behavior
2013-12-03 Scientific
A single intramuscular injection of rAAV-mediated mutant erythropoietin protects against MPTP-induced parkinsonism, Mar;12(2):224-33.
PLoS One
2011-01-01 Scientific Michael P McDonald
Intracranial V. cholerae sialidase protects against kainate-induced neurodegeneration, 6(12):e29285.
Neuroscience and Biobehavioral Review
2008-01-01 Scientific Shetty AK
Is Exposure to Enriched Environment Beneficial for Functional Post-Lesional Recovery in Temporal Lobe Epilepsy? , 32(4):657-74.
Behavioral Neuroscience
2009-01-01 Scientific Rehka J Sridhara C Venna LR Kalai Vani P
Transplantation of Hippocampal cell lines improves spatial learning in rats with ventral subicular lesion, 123(6):1197-217.
Behavioral Neuroscience
2007-01-01 Scientific Bindu B Raju TR Kutty BM
Exposure to Enriched Environment Improves Spatial Learning Performances and Enhances Cell Density But Not Choline Acetyltransferase Activity in The Hippocampus Of Ventral Subicular- Lesioned Rats, 121(3):491-500.
Brain Reseach Bulletin
2003-15-02 Scientific Sreekumaran E Ramakrishna T Madhav TR Sulekha S
Loss of Dendritic Connectivity in CA1, CA2 And CA3 Neurons in Hippocampus in Rat Under Aluminum Toxicity: Antidotal Effect of Pyridoxine, Feb 15;59(6):421-7.
Biomed Pharmacother
2017-27-09 Scientific Sanap A Chandravanshi B Shah T Tillu G D Anandh Bhonde R Joshi K Dhanushkodi A
Herbal pre-conditioning induces proliferation and delays senescence in Wharton's Jelly Mesenchymal Stem Cells. . 2017 Sep;93:772-778.
Neural Regen Res
2015-10-12 Scientific Shamir C Venugopal C D Anandh Dhanushkodi A
Dental pulp stem cells for treating neurodegenerative diseases. Neural Regen Res. 2015 Dec;10(12):1910-1.
Rev Diabet Stud.
2014-27-06 Scientific Chandravanshi B Dhanushkodi A D Anandh Bhonde R
High Recovery of Functional Islets Stored at Low and Ultralow Temperatures. Rev Diabet Stud. 2014 Fall-Winter;11(3-4):267-78.
J Tissue Eng Regen Med.
2017-11-02 Scientific Venugopal C Chandanala S Prasad HC Nayeem D D Anandh Dhanushkodi A Bhonde R
Regenerative therapy for hippocampal degenerative diseases: lessons from preclinical studies. J Tissue Eng Regen Med. 2017 Feb;11(2):321-333.
J Toxicol.
2014-27-09 Scientific Bevinahal PK Venugopal C Yencharla HC Chandanala S D Anandh Talakad SN Bhonde RR Dhanushkodi A Trichur RR
Conditioned Medium Reconditions Hippocampal Neurons against Kainic Acid Induced Excitotoxicity: An In Vitro Study. 194967.
Neurotoxicology
2017-06-12 Scientific Prasad YSHC Venugopal C Dhanushkodi A Pinnelli VB Shobha K
HEK-293 secretome attenuates kainic acid neurotoxicity through insulin like growth factor-phosphatidylinositol-3-kinases pathway and by temporal regulation of antioxidant defense machineries.
Curr Gene Ther
2018-24-01 Scientific Shamir C Venugopal C Dhanushkodi A Shobha K Rai KS Nishtha KJ Sonu PK Babu JV Senthilkumar S
Dosage and Passage Dependent Neuroprotective Effects of Exosomes Derived from Rat Bone Marrow Mesenchymal Stem Cells: An In Vitro Analysis.
Publication : https://doi.org/10.1016/j.lfs.2024.123019