Dr. Sangeeta Nath
Assistant Professor- Research
Manipal Institute of Regenerative Medicine
Qualification: PhD
CURRENT ACADEMIC ROLE & RESPONSIBILITIES
Assistant Professor (Research) in Manipal Institute of Regenerative Medicine, MAHE, Bengaluru.
ACADEMIC QUALIFICATIONS
| Degree | Specialisation | Institute | Year of passing |
|---|---|---|---|
| PhD | Biophysics/Biochemistry | Indian Institute of Chemical Biology | 2007 |
| M.Tech | Biotechnology | Jadavpur University | 2002 |
| B.Pharm | Pharmacy | Jadavpur University | 2000 |
Experience
| Institution / Organisation | Designation | Role | Tenure |
|---|---|---|---|
| Manipal Institute of Regenerative Medicine, MAHE, Bengaluru | Assistant Professor (Research) | 2019-Present | |
| Institute of Stem cell & Regenerative Medicine, Bengaluru | Technologist | Developed ultra-fast single particle tracking microscope | 2016-2019 |
| Kyoto University,Japan | Visiting researcher | Joint program between inStem, Bangalore and iCeMS, Kyoto University | 2016-2017 |
| Linkoping University, Sweden | Principal Research Engineer (Förste forskningsingenjör) | Permanent research staff position | 2012-2015 |
| Linkoping University, Sweden | Post-Doctoral Fellow | 2010 - 2012 | |
| Katholieke Universiteit Leuven, Belgium. | Post-Doctoral Fellow | 2007 - 2009 |
Research Focus:
Dr. Nath's research focuses on understanding the direct transfer of toxic organelles like mitochondria and lysosomes between cells and their role in neurological diseases.
AREAS OF INTEREST, EXPERTISE AND RESEARCH
Area of Interest
Cellular mechanism of gradual pathology progression in neurodegenerative diseases.
Area of Expertise
Neurodegenerative diseases, Protein chemistry, Protein aggregation, Fluorescence spectroscope and microscopes, Single molecule super-resolution microscopes.
Area of Research
My research interest is broadly on understanding of cellular mechanism of gradual pathology progression in neurodegenerative diseases.
Professional Affiliations & Contributions
My research interest is broadly on understanding of cellular mechanism of gradual pathology progression in neurodegenerative diseases. Additionally, we work on characterizations of transient aggregates in Alzheimer’s and Parkinson’s diseases and their relevance in oxidative cellular stress (Nath et al. Biophysical J. 2010; Nath et al. Mol. Cell. Neurosc. 2010 and Goodwin et al. Neurochem Int. 2013). Our research works have indicated that spreading of pathology in Alzheimer’s disease is due to direct cell-to-cell transfer of amyloidogenic oligomers and lysosomal stress/accumulations enhance its progression ((Domert et al. Neurobiol Dis. 2014; Nath et al. J. Neurosci. 2012; Hallbeck et al. Neuroscientist. 2013). We are also interested in lysosomal stress and membrane leakage in Parkinson’s model (Nath & Eriksson et.al. Eur J Cell Biol, 2017). Microscopic observations of direct-cell-to-cell transfer of oligomers also indicated formation of tunnelling nanotube structures.
Google scholar link : https://scholar.google.com/citations user=LpzUaScAAAAJ&hl=en
Manipal pure: https://researcher.manipal.edu/en/persons/sangeeta-nath
1. Abinaya Raghavan; Pooja Rao; Jiri Neuzil; Dean L Pountney; *Sangeeta Nath (2021) Oxidative stress and Rho GTPases in the biogenesis of tunnelling nanotubes: Implications in disease and therapy. Cellular and Molecular Life Sciences (2021) 18; 79 (1) : 36.
2. Aysha Dilna, K.V Deepak, Nandini Damodaran, Claudia Sybille Kielkopf, Karin Ollinger, Katarina Kagedal, *Sangeeta Nath. Amyloid-β induced membrane damage instigates tunnelling nanotube-like conduits by p21-activated kinase dependent actin remodulation BBA-Mol Basis Dis. 1876 (12):166246 (2021).
3. Zhiming Ma, Xiaolin Liu, Sangeeta Nath, He Sun, Tuan Tran, Liang Yang, Satyajit Mayor, Yansong Miao. Formin Nano-clustering Mediated Actin Assembly during Plant flagellin and DSF-signalings. Cell Reports 34(13):108884 (2021).
4. Tuan Minh Tran, Zhiming Ma, Alexander Triebl, Sangeeta Nath, Yingying Cheng, Ben-Qiang Gong, Xiao Han, Junqi Wang, Jian-Feng Li, Markus R. Wenk, Federico Torta, Satyajit Mayor, Liang Yang, Yansong Miao. The bacterial quorum sensing signal DSF hijacks Arabidopsis thaliana sterol biosynthesis to suppress plant innate immunity. Life Science Alliance (2020).
5. Parijat Sil1, Nicolas Mateos, Sangeeta Nath, Sonja Buschow, Carlo Manzo, Kenichi G. N. Suzuki, Takahiro Fujiwara, Akihiro Kusumi, Maria F. Garcia-Parajo and Satyajit Mayor. Dynamic actin mediated nano-scale clustering of CD4 regulates its meso-scale organization at the plasma membrane. Mol Biol of Cell 7: 561-579; (2020).
6. Sangeeta Nath, Ida Eriksson, Per Bornefall, Ana Maria Villamil Giraldo, Karin Öllinger. Impact of high cholesterol in a Parkinson’s disease model: Prevention of lysosomal leakage versus stimulation of α-synuclein aggregation. Euro J of Cell Biol 96: 99-109; (2017).
7. Linnea Sandin, Liza Bergkvist, Sangeeta Nath, Claudia Kielkopf, Camilla Janefjord, Linda Helmfors, Henrik Zetterberg, Kaj Blennow, Hongyun Li, Camilla Nilsberth, Brett Garner, Ann Christin Brorsson, and Katarina Kågedal, Beneficial effects of increased lysozyme levels in Alzheimer's disease modelled in Drosophila melanogaster. FEBS J 19:3508-3522; (2016).
8. Linda Helmfors, Andrea Boman, Livia Civitelli, Sangeeta Nath, Linnea Sandin, Camilla Janefjord, Heather McCann, Henrik Zetterberg, Kaj Blennow, Glenda Halliday, Ann-Christin Brorsson, Katarina Kågedal. Protective properties of lysozyme on β-amyloid pathology; Implications for Alzheimer disease. Neurobiology of Disease 83:122-133, (2015).
9. Lotta Agholme, Sangeeta Nath, Jakob Domert, Jan Marcusson, Katarina Kågedal, Martin Hallbeck. Proteasome Inhibition Induces Stress Kinase Dependent Transport Deficits–Implications for Alzheimer’s Disease. Mol Cell Neurosci 58:29-39, (2014).
10. Jakob Domert, Sahana Bhima Rao, Lotta Agholme, Ann-Christin Brorsson, Jan Marcusson, Martin Hallbeck, Sangeeta Nath*. Spreading of amyloid-β peptides via neuritic cell-to-cell transfer is dependent on insufficient cellular clearance. Neurobiology of Disease 65:82-92, (2014).
11. Martin Hallbeck, Sangeeta Nath, Jan Marcusson, Neuron-to-neuron transmission of neurodegenerative pathology. Neuroscientist 19:560-566, (2013).
12. Sangeeta Nath*, Lotta Agholme, Firoz Roshan Kurudenkandy, Björn Granseth, Jan Marcusson, Martin Hallbeck*. Spreading of neurodegenerative pathology by neuron to neuron transmission of β amyloid. J Neurosci. 32:8767-8777 (2012). Published as Issue Highlights in this issue and highlighted in Science News in July 14 (digital), ‘Title: Alzheimer’s may be handiwork of ‘prion’ proteins: A-beta moves from cell-to-cell, spreading destruction.’ 2012-page 4-5).
13. Jacob Goodwin, Sangeeta Nath, Yves Engelborghs, Dean Louis Pountney, Raised calcium and oxidative stress cooperatively promote alpha-synuclein aggregate formation. Neurochem Int. 62:703-711(2013).
14. Sangeeta Nath, Manli Deng, Yves Engelborghs. Fluorescence correlation spectroscopy to determine the diffusion coefficient of α-synuclein and follow early oligomer formation. Methods Mol Biol. (Uversky, Vladimir N.; Dunker, A. Keith Eds.) 895:499-506 (2012).
15. Sangeeta Nath, Jessika Meuvis, Jelle Hendrix, Shaun A. Carl, Yves Engelborghs. Early aggregation steps in α-synuclein as measured by Fluorescence Correlation Spectroscopy and Forster Resonance Energy Transfer. Evidence for a contagious conformational state. Biophysical J. 98:1-10 (2010).
16. Sangeeta Nath, Jacob Goodwin, Yves Engelborghs. Dean Louis Pountney, Raised calcium promotes α-synuclein aggregate formation. Mol Cell Neurosci. 46:516-26 (2010).
17. Smitha Rao, Katrijn Bockstael, Sangeeta Nath, Yves Engelborghs, Jozef Anné, Nick Geukens. Biochemical characterization of Staphylococcus aureus type I signal peptidase, SpsB. FEBS J. 276:3222-34 (2009).
18. Sangeeta Nath, Debasish Bhattacharyya. Cell adhesion by aqueous extract of human placenta used as wound healer. Indian J. Expt. Biol. 45(2007) 732-738.
19. Sangeeta Nath, Amrita Brahma, Debasish Bhattacharyya. Extended application of gel permeation chromatography spin column. Anal. Biochem 320:199-206 (2003).