Dr. Urmi Bandyopadhyay

Ramalingaswami Re-entry Fellow

Dr. Urmi Bandyopadhyay is interested in understanding the fundamental molecular principles of lysosomal-amino acid (AA) storage and homeostasis in response to altered extracellular-environment, and its pathophysiological significance. She did her Ph.D. in Dr. Ana Maria Cuervo’s laboratory at Albert Einstein College of Medicine (USA), on Chaperone-Mediated-Autophagy (selective-Autophagy), that has profound importance in neurodegeneration. During her first postdoctoral-research, in Dr. Arthur Horwich’s laboratory at Yale University (USA), she applied her autophagy-lysosome-biology knowledge in the field of neurodegeneration – ALS-disease. She further pursued her interest in lysosome-biology in Dr. Michael Overholtzer’s laboratory in Memorial Sloan Kettering Cancer Center (USA). There she discovered a novel, conserved, lysosomal AA storage-homeostasis-pathway in response to extracellular-environment, which is important for supporting intracellular-translation in nutrient-scarcity and has pathophysiological significance. She will pursue this current research in her laboratory, especially, by exploring: 1) regulatory mechanisms and 2) altered function of this novel-AA-homeostasis in diseases, including cancer, neurodegeneration, aging.

Manipal Institute of Regenerative Medicine

Qualification: Ph.D.

CURRENT ACADEMIC ROLE & RESPONSIBILITIES

      Dr. Urmi Bandyopadhyay  is a Ramalingaswami Re-entry Fellow in Manipal Institute of Regenerative Medicine, MAHE, Bengaluru.

       

      She:

      • Conducts theory and practical classes.
      • Is involved in conducting examinations and checking exam papers.
      • Is guide for student dissertations (PG/PhD).
      • Writes projects for research funding.

SUBJECTS CURRENTLY TEACHING

Subject Semester / Year
Biomolecules I st semester

ACADEMIC QUALIFICATIONS

Degree Specialisation Institute Year of passing
Ph.D. Cell Biology

AREAS OF INTEREST, EXPERTISE AND RESEARCH

Area of Research

Cell Biology, Lysosome Biology, Autophagy, Neurodegeneration, Amino Acid Homeostasis

  1. Bandyopadhyay U*, Todorova P, Pavlova NN, Tada Y, Thompsom C*, Finley LWS, Overholtzer M*. Leucine retention in lysosomes is regulated by starvation. Proc Natl Acad Sci USA. 2022 Feb 8. 119 (6) e2114912119; https://doi.org/10.1073/pnas.2114912119
  2. ·       Ying J, Sato Y, Im E, Berg M, Bordi M, Darji S, Kumar A, Mohan P, Bandyopadhyay U, Diaz A, Cuervo AM, and Nixon R*. Lysosomal dysfunction in Down syndrome is APP-dependent and mediated by APP-βCTF (C99). Journal of Neuroscience. 2019 May, 0578-19; DOI: https://doi.org/10.1523/JNEUROSCI.0578-19.2019

    Google scholar link :