Dr. Amanjot Singh
Faculty Fellow (India Alliance Wellcome-DBT Intermediate Fellow)
Dr. Amanjot Singh is a DBT-Wellcome Trust India Alliance Intermediate Fellow in Manipal Institute of Regenerative Medicine, MAHE, Bengaluru. He Conducts theory classes. He is involved in conducting examinations and checking exam papers. He is guide for student dissertations. He writes projects for research funding.
Manipal Institute of Regenerative Medicine
Qualification: Ph. D
CURRENT ACADEMIC ROLE & RESPONSIBILITIES
- Conducts theory classes
- Is involved in conducting examinations and checking exam papers
- Is guide for student dissertations
- Writes projects for research funding
Dr. Amanjot Singh is a DBT-Wellcome Trust India Alliance Intermediate Fellow in Manipal Institute of Regenerative Medicine, MAHE, Bengaluru
He:
ACADEMIC QUALIFICATIONS
| Degree | Specialisation | Institute | Year of passing |
|---|---|---|---|
| Ph. D | Molecular Biology | University of Delhi South Campus, New Delhi | 2009 |
AREAS OF INTEREST, EXPERTISE AND RESEARCH
Area of Interest
Protein quality control (PQC) system, which include chaperones and components of proteasome, ubiquitin, autophagy and lysosomal systems play important roles in almost all aspects of biology. Recent research has revealed new roles for PQC in dynamics of biological condensates (such as stress granules (SGs)) which are rapidly reversible assemblies formed via quinary interactions (which are both transient and multivalent) among the component RNAs and proteins. Such condensates sequester proteins involved in specific biological pathways or serve as an environment for the management of misfolded proteins. High concentration of misfolded and disordered proteins in condensates makes them prone to support formation of pathogenic protein aggregates of an irreversible nature. Work in the lab involves elucidating how the PQC is involved in the dynamics of condensates/SGs. We also test the molecular basis of such sequestration of other proteins in SGs or pathological aggregates and how this rewires cellular homeostasis during stress, aging and neurodegeneration.
Area of Expertise
Molecular Biology, Biochemistry, Cell Biology
Area of Research
My research interest broadly involves understanding how cellular homeostasis is maintained under stress, aging and neurodegeneration
Professional Affiliations & Contributions
Member of the following societies:
- Biochemical Society, UK
Singh A*, Kandi AR#, Jayaprakashappa D#, Thuery G, Purohit DJ, Huelsmeier J, Singh R, Pothapragada SS, Ramaswami M* and Bakthavachalu B* (2022) The transcriptional response to oxidative stress is independent of stress granule formation. Molecular Biology of the Cell 33:ar25, 1-16. (*Co-corresponding authors, # equal contribution)
Singh A*, Huelsmeier J*, Kandi AR, Pothapragada SS, Hillebrand J, Petrauskas A, Agarwal K, Krishnan RT, Thiagarajan D, Jayaprakashappa D, VijayRaghavan K, Ramaswami M and Bakthavachalu B (2021) Antagonistic roles for Ataxin-2 structured and disordered domains in RNP condensation. eLife 10:e60326 (*Equal contribution)
Singh A*, Vashistha N, Heck J, Tang X, Wipf P, Brodsky J, Hampton RY* (2020) Direct involvement of HSP70 ATP hydrolysis in Ubr1-dependent quality control. Molecular Biology of the Cell 31 (24) 2669-2686 (* Corresponding authors) “A Highlights from MBoC Selection”
Bakthavachalu B, Huelsmeier J, Sudhakaran I, Hillebrand J, Singh A, Petrauskas A, Thiagarajan D, Sankaranarayanan M, Mizoe L, Anderson E, Pandey UB, Ross E, VijayRaghavan K, Parker R and Ramaswami M (2018) RNP-granule assembly via Ataxin-2 disordered domains is required for long-term memory and neurodegeneration. Neuron 98: 754-766.
Vashistha N, Neal S, Singh A, Caroll S and Hampton RY (2016) Direct and essential function for Hrd3 in ER-associated degradation. Proceedings of the National Academy of Sciences USA 113: 5934-5939.