CURRENT ACADEMIC ROLE & RESPONSIBILITIES
- Facility In-charge: Mass Spectrometry
- Coordinates PhD Program and Masters (by Research in Life Sciences) Program
- Teaching & Research assignments for PhD, Masters and Bachelors degree programs
Manjunath B Joshi is Professor in the Department of Ageing research at the Manipal School of Life Sciences.
|Degree||Specialisation||Institute||Year of passing|
|PhD||Vascular Biology||University of Basel, Switzerland||2007|
|Institution / Organisation||Designation||Role||Tenure|
|School of Life Sciences MAHE, Manipal||Associate Professor||August 2016-Present|
|School of Life Sciences MAHE, Manipal||Assistant Professor||August 2011- August 2016|
|University Hospital, Basel, Switzerland||Post-doctoral fellow||July 2007 – July 2011|
|University Hospital, Basel, Switzerland||PhD Student||October 2003-July 2007|
|Center for Cellular and Molecular Biology, Hyderabad, India||Junior Research Fellow||April 2001-October 2003|
Epigenetic changes in endothelial cells due to stromal interactions: consequence in tumor angiogenesis
Funded by DBT, Government of India.
Functional and structural characterization of snake venom proteins from Bothrops atrox with angiogenic potential
Funded by Indo-Brazil Project, DBT
Design and expression of Humanized antibody against soluble IL6R & GP130 in bacteria and animal cell line
Funded by DBT-BIRAP
AREAS OF INTEREST, EXPERTISE AND RESEARCH
Area of Interest
Cell biology, Biochemistry, Immunology, Type 2 Diabetes
Area of Expertise
Vascular biology, Neutrophil biology, Cell signalling, Metabolomics
Area of Research
Vascular insulin resistance, metabolic memory, tumor angiogenesis, neutrophil extracellular traps
Professional Affiliations & Contributions
Life Member for following societies:
- Society for Mitochondria Research and Medicine, India
- Society of Biological Chemists
- Environmental mutagenesis society of India
Awards and Honours:
- Travel award by European society of cardiology for oral presentation at European Society of cardiology meeting, Vienna, September 2007.
- Travel award for Erasmus mundus Program, Biohealth Computing (BioHC), Joseph Fourier University, Grenoble. 24th August-7th September, 2013.
- Best poster award: Indo-US symposium on “Mass spectrometry based metabolomics in disease biology” Trivandrum, India. January 2014.
- Dr. TMA Pai Gold medal for best research publication in 2016. MAHE, Manipal, April 2017.
High glucose modulates IL-6 mediated immune homeostasis through impeding neutrophil extracellular traps formation in diabetic conditions
2013-01-01 Lad A Bharat Prasad A Balakrishna A Ramachandra L
2013, FEBS Letters, Elsevier, Vol 587, Pg 2241-6.
BRN-2 is a transcriptional repressor of CDH-13 (T-cadherin) in melanoma cells
2012-01-01 Ellmann L Resink TJ Bosserhoff A Kuphal S
2012, Nature Publications, Vol 92, Pg 1788-800.
T-cadherin is an auxiliary negative regulator of EGFR pathway activity in cutaneous squamous cell carcinoma: impact on cell motility
2012-01-01 Kyriakakis E Maslova K Philippova M Pfaff D
2012, Journal of Investigative Dermatology, Vol 132, Pg 2275-85.
T-cadherin attenuates insulin-dependent signalling, eNOS activation and angiogenesis in vascular endothelial cells
2012, Cardio Vascular Research, Vol 93, Pg 498-507.
T-cadherin is present on endothelial micro-particles and is elevated in plasma in early atherosclerosis
2011-01-01 Philippova M Suter Y Toggweiler S Schoenenberger AW
2011, European Heart Journal, Vol 32, Pg 760-71.
Activated endothelial cells induce neutrophil extracellular traps and are susceptible to NETosis-mediated cell death
2010, FEBS Letters, Elsevier, Vol 584, Pg 3193-7.
T-cadherin attenuates the PERK branch of the unfolded protein response and protects vascular endothelial cells from endoplasmic reticulum stress-induced apoptosis
2010-01-01 Kyriakakis E Philippova M Pfaff D Bochkov V
2010, Cellular Signalling, Vol 22, Pg 1308-16.
Extracellular cadherin repeat domains EC1 and EC5 of T-cadherin are essential for its ability to stimulate angiogenic behaviour of endothelial cells
2009-01-01 Kyriakakis E Pfaff D Rupp K Philippova M
2009, FASEB Journal, Vol 23, Pg 4011-21.
A guide and guard: the many faces of T-cadherin
2009-01-01 Philippova M Kyriakakis E Pfaff D Erne P
2009, Cellular Signalling, Vol 21, Pg 1035-44.
Cadherins and cardiovascular disease
2009, Swiss Medical Weekly, Vol 139, Pg 122-34.
Quantitative Analysis of Phyllanthus amarus and Phyllanthus urinaria for Bioactive Molecules using High-Pressure Liquid Chromatography and Liquid Chromatography–Mass Spectrometry
Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci. 2017
Elevated homocysteine levels in type 2 diabetes induce constitutive neutrophil extracellular traps
2016-14-10 Joshi MB Baipadithaya G Balakrishna A Hegde M Vohra M Ahamed R Nagri SK Ramachandra L Satyamoorthy K
Sci Rep ; 6:36362, 2016
Full Publications List
Peptides for promoting angiogenesis and a method of synthesizing the same
(Indian patent filed).
Identification of proteins in unstained page (1d and 2d) by laser induced auto fluorescence
Krishna Kishore Mahato Manjunath Siddaramaiah Satyamoorthy K Manjunath B. Joshi Anirbit Datta Subhash Chandra
(Indian patent filed).
Genetic and Epigenetic Analysis of Genes Encoding Phosphoenolpyruvate Carboxykinase Isoforms in Human Cells
Delineating epigenetic mechanisms under the conditions of vascular insulin resistance: implications in cardiovascular diseases
Influence of IL-6 on DNA methylation changes in cancer and endothelial cells upon interaction with tumor infiltrated neutrophils
Influence of glucose on crosstalk between DNA methyltransferases and HMGB1 in endothelial cells: Implications on Metabolic Memory
Influence of homocysteine on neutrophil extracellular traps and its implications in stroke
Evaluation of antiatherogenic effects of simvastatin, ω-3 fatty acids, caffeic acid and berberine against atherosclerosis induced through nf-κb pathway in rats
Neutrophil activation in diabetic conditions
2011-01-01 Apurva Lad
MSc II Year, 2011.
Alterations in extracellular matrix proteins under hypoxic condition in hepatocarcinoma cell line
2011-01-01 Shilpa Patil
BSc V sem, 2011.
Understanding the metabolic processes involved in neuritogenesis using high throughput metabolomics approach
2012-01-01 Pranoy Sahu
BSc V sem, 2012.