Dr Manjunath B Joshi


Department of Ageing Research


    Manjunath B Joshi is Professor in the Department of Ageing research at the Manipal School of Life Sciences.


    • Facility In-charge: Mass Spectrometry
    • Coordinates PhD Program and Masters (by Research in Life Sciences) Program
    • Teaching & Research assignments for PhD, Masters and Bachelors degree programs


Degree Specialisation Institute Year of passing
PhD Vascular Biology University of Basel, Switzerland 2007


Institution / Organisation Designation Role Tenure
School of Life Sciences MAHE, Manipal Associate Professor August 2016-Present
School of Life Sciences MAHE, Manipal Assistant Professor August 2011- August 2016
University Hospital, Basel, Switzerland Post-doctoral fellow July 2007 – July 2011
University Hospital, Basel, Switzerland PhD Student October 2003-July 2007
Center for Cellular and Molecular Biology, Hyderabad, India Junior Research Fellow April 2001-October 2003

Epigenetic changes in endothelial cells due to stromal interactions: consequence in tumor angiogenesis

Funded by DBT, Government of India.

Functional and structural characterization of snake venom proteins from Bothrops atrox with angiogenic potential

Funded by Indo-Brazil Project, DBT

Design and expression of Humanized antibody against soluble IL6R & GP130 in bacteria and animal cell line

Funded by DBT-BIRAP


Area of Interest

Cell biology, Biochemistry, Immunology, Type 2 Diabetes

Area of Expertise

Vascular biology, Neutrophil biology, Cell signalling, Metabolomics

Area of Research

Vascular insulin resistance, metabolic memory, tumor angiogenesis, neutrophil extracellular traps

Professional Affiliations & Contributions


Life Member for following societies:

  • Society for Mitochondria Research and Medicine, India
  • Society of Biological Chemists
  • Environmental mutagenesis society of India


Awards and Honours:

  • Travel award by European society of cardiology for oral presentation at European Society of cardiology meeting, Vienna, September 2007.
  • Travel award for Erasmus mundus Program, Biohealth Computing (BioHC), Joseph Fourier University, Grenoble. 24th August-7th September, 2013.
  • Best poster award: Indo-US symposium on “Mass spectrometry based metabolomics in disease biology” Trivandrum, India. January 2014.
  • Dr. TMA Pai Gold medal for best research publication in 2016.  MAHE, Manipal, April 2017.


High glucose modulates IL-6 mediated immune homeostasis through impeding neutrophil extracellular traps formation in diabetic conditions

2013-01-01 Lad A Bharat Prasad A Balakrishna A Ramachandra L

2013, FEBS Letters, Elsevier, Vol 587, Pg 2241-6.

BRN-2 is a transcriptional repressor of CDH-13 (T-cadherin) in melanoma cells

2012-01-01 Ellmann L Resink TJ Bosserhoff A Kuphal S

2012, Nature Publications, Vol 92, Pg 1788-800.

T-cadherin is an auxiliary negative regulator of EGFR pathway activity in cutaneous squamous cell carcinoma: impact on cell motility

2012-01-01 Kyriakakis E Maslova K Philippova M Pfaff D

2012, Journal of Investigative Dermatology, Vol 132, Pg 2275-85.

T-cadherin attenuates insulin-dependent signalling, eNOS activation and angiogenesis in vascular endothelial cells

Philippova M Pfaff D Kyriakakis E Maslova K

2012, Cardio Vascular Research, Vol 93, Pg 498-507.

T-cadherin is present on endothelial micro-particles and is elevated in plasma in early atherosclerosis

2011-01-01 Philippova M Suter Y Toggweiler S Schoenenberger AW

2011, European Heart Journal, Vol 32, Pg 760-71.

Activated endothelial cells induce neutrophil extracellular traps and are susceptible to NETosis-mediated cell death

Gupta AK Hasler P Erne P Hahn S

2010, FEBS Letters, Elsevier, Vol 584, Pg 3193-7.

T-cadherin attenuates the PERK branch of the unfolded protein response and protects vascular endothelial cells from endoplasmic reticulum stress-induced apoptosis

2010-01-01 Kyriakakis E Philippova M Pfaff D Bochkov V

2010, Cellular Signalling, Vol 22, Pg 1308-16.

Extracellular cadherin repeat domains EC1 and EC5 of T-cadherin are essential for its ability to stimulate angiogenic behaviour of endothelial cells

2009-01-01 Kyriakakis E Pfaff D Rupp K Philippova M

2009, FASEB Journal, Vol 23, Pg 4011-21.

A guide and guard: the many faces of T-cadherin

2009-01-01 Philippova M Kyriakakis E Pfaff D Erne P

2009, Cellular Signalling, Vol 21, Pg 1035-44.

Cadherins and cardiovascular disease

Resink TJ Philippova M Kyriakakis E Erne P

2009, Swiss Medical Weekly, Vol 139, Pg 122-34.

Quantitative Analysis of Phyllanthus amarus and Phyllanthus urinaria for Bioactive Molecules using High-Pressure Liquid Chromatography and Liquid Chromatography–Mass Spectrometry

2017-05-01 Muthusamy A Sanjay ER Nagendra Prasad HN Rao RM Vidhu SB Joshi MB Rai PS Satyamoorthy K

Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci. 2017

Elevated homocysteine levels in type 2 diabetes induce constitutive neutrophil extracellular traps

2016-14-10 Joshi MB Baipadithaya G Balakrishna A Hegde M Vohra M Ahamed R Nagri SK Ramachandra L Satyamoorthy K

Sci Rep ; 6:36362, 2016

Full Publications List


Peptides for promoting angiogenesis and a method of synthesizing the same

Satyamoorthy K Manjunath B Joshi Shreesha Bhat Raghuvir Arni Selthur Govind Biligiri

(Indian patent filed).

Identification of proteins in unstained page (1d and 2d) by laser induced auto fluorescence

Krishna Kishore Mahato Manjunath Siddaramaiah Satyamoorthy K Manjunath B. Joshi Anirbit Datta Subhash Chandra

(Indian patent filed).

Genetic and Epigenetic Analysis of Genes Encoding Phosphoenolpyruvate Carboxykinase Isoforms in Human Cells

Venu S

Delineating epigenetic mechanisms under the conditions of vascular insulin resistance: implications in cardiovascular diseases

Aswath Balakrishnan

Influence of IL-6 on DNA methylation changes in cancer and endothelial cells upon interaction with tumor infiltrated neutrophils

Mangala Hegde

Influence of glucose on crosstalk between DNA methyltransferases and HMGB1 in endothelial cells: Implications on Metabolic Memory

Sampara Vasistha

Influence of homocysteine on neutrophil extracellular traps and its implications in stroke

Aswathi Nair

Evaluation of antiatherogenic effects of simvastatin, ω-3 fatty acids, caffeic acid and berberine against atherosclerosis induced through nf-κb pathway in rats

Sushma Reddy

Neutrophil activation in diabetic conditions

2011-01-01 Apurva Lad

MSc II Year, 2011.

Alterations in extracellular matrix proteins under hypoxic condition in hepatocarcinoma cell line

2011-01-01 Shilpa Patil

BSc V sem, 2011.

Understanding the metabolic processes involved in neuritogenesis using high throughput metabolomics approach

2012-01-01 Pranoy Sahu

BSc V sem, 2012.