CURRENT ACADEMIC ROLE & RESPONSIBILITIES
- Guides doctoral, post-graduate and graduate students for various research projects
- Involved in molecular diagnostics of genetic disorders
Sanjiban Chakrabarty is Associate Professor in the Department of Cell and Molecular Biology at the Manipal School of Life Sciences.
|Degree||Specialisation||Institute||Year of passing|
|PhD||Human Genetics||School of Life Sciences, MAHE, Manipal||2013|
|Institution / Organisation||Designation||Role||Tenure|
|School of Life Sciences/Manipal Academy of Higher Education||Assistant Professor||2013-present|
|Molecular Genetics, Erasmus Medical Center, The Netherlands||Postdoctoral Fellow||2018-2019|
AREAS OF INTEREST, EXPERTISE AND RESEARCH
Area of Interest
Molecular mechanism of carcinogenesis and chemotherapeutic resistance
Area of Expertise
Genome analysis, mitochondrial biology
Area of Research
Nuclear mitochondrial crosstalk in cancer progression and chemotherapeutic resistance
Professional Affiliations & Contributions
- Executive Committee Member of Society for Mitochondrial Research and Medicine-India
- Life Member of European Association For Cancer Research (EACR).
- Life Member of Society of Biological Chemists, India
- Life Member of Environmental Mutagen Society of India.
Awards and Honors:
Australia awards fellowships program entitled “Metagenomics guided management of drug resistant tuberculosis and HIV: advances in diagnostics” in collaboration with University of Sydney, 2017.
|Invitrogen Bioservices||Business Development Manager||2013-2013|
|Ecron Acunova (Formerly known as Manipal Acunova), Bangalore||Scientist||2005 - 2007|
Targeted sequencing-based analyses of candidate gene variants in ulcerative colitis-associated colorectal neoplasia
2017-18-05 Br J Cancer.
Chakrabarty S, Varghese VK, Sahu P, Jayaram P, Shivakumar BM, Pai CG, Satyamoorthy K.
Epigenomics, Pharmacoepigenomics, and Personalized Medicine in Cervical Cancer
2017-19-05 Public Health Genomics
Kabekkodu SP, Chakrabarty S, Ghosh S, Brand A, Satyamoorthy K.
Aberrant gene-specific DNA methylation signature analysis in cervical cancer
2017-01-03 Tumour Biol
Bhat S, Kabekkodu SP, Varghese VK, Chakrabarty S, Mallya SP, Rotti H, Pandey D, Kushtagi P, Satyamoorthy K
DNA methylation detection at single base resolution using targeted next generation bisulfite sequencing and cross validation using capillary sequencing
Bhat S, Mallya S, Varghese VK, Jayaram P, Chakrabarty S, Joshi KS, Nesari TM, Satyamoorthy K
Spastizin mutation in hereditary spastic paraplegia with thin corpus callosum
2016-01-08 J Neurol
Chakrabarty S, Vijayakumar N, Radhakrishnan K, Satyamoorthy K
Comparative analysis of copy number variations in ulcerative colitis associated and sporadic colorectal neoplasia
2016-01-04 BMC Cancer
Shivakumar BM, Chakrabarty S, Rotti H, Seenappa V, Rao L, Geetha V, Tantry BV, Kini H, Dharamsi R, Pai CG, Satyamoorthy K
Perspectives on Translational Genomics and Public Health in India
2016-01-02 Public Health Genomics
Chakrabarty S, Kabekkodu SP, Brand A, Satyamoorthy K
Genome Sequence of a Burkholderia pseudomallei Clinical Isolate from a Patient with Community-Acquired Pneumonia and Septicemia
2015-01-08 Genome Announc
Mukhopadhyay C, Vandana KE, Chaitanya TA, Shaw T, Bhat HV, Chakrabarty S, Paul B, Mallya S, Murali TS, Satyamoorthy K
Mitochondrial biology: From molecules to diseases
Kabekkodu SP, Chakrabarty S, Shukla V, Varghese VK, Singh KK, Thangaraj K, Satyamoorthy K
DNA methylation analysis of phenotype specific stratified Indian population
2015-01-05 J Transl Med
Rotti H, Mallya S, Kabekkodu SP, Chakrabarty S, Bhale S, Bharadwaj R, Bhat BK, Dedge AP, Dhumal VR, Gangadharan GG, Gopinath PM, Govindaraj P, Joshi KS, Kondaiah P, Nair S, Nair SN, Nayak J, Prasanna BV, Shintre P, Sule M, Thangaraj K, Patwardhan B, Valiathan MV, Satyamoorthy K
Copy number variations are progressively associated with the pathogenesis of colorectal cancer in ulcerative colitis
2015-01-01 World J Gastroenterol
Shivakumar BM, Rotti H, Vasudevan TG, Balakrishnan A, Chakrabarty S, Bhat G, Rao L, Pai CG, Satyamoorthy K
Upregulation of TFAM and mitochondria copy number in human lymphoblastoid cells
Chakrabarty S, D'Souza RR, Kabekkodu SP, Gopinath PM, Rossignol R, Satyamoorthy K
Comprehensive DNA copy number profile and BAC library construction of an Indian individual
Chakrabarty S, D'Souza RR, Bellampalli R, Rotti H, Saadi AV, Gopinath PM, Acharya RV, Govindaraj P, Thangaraj K, Satyamoorthy K
Methylation markers: a potential force driving cancer diagnostics forward
2011-03-06 Oncol Res
Khandige S, Shanbhogue VV, Chakrabarty S, Satyamoorthy K
Antioxidants and lipid peroxidation in gestational diabetes--a preliminary study
2008-01-04 Indian J Physiol Pharmacol
Dey P, Gupta P, Acharya NK, Rao SN, Ray S, Chakrabarty S, Ramprasad S, Kurian TA, Mawroh A, Kundu A, Bhaktha G, Joseph CP, Kumar P, Rai L, Rao A
Full Publications List
Implication of TFAM gene mutations in neurodegenerative disorders
2012-01-01 Anush Rajendran
PG, MSc Medical Biotechnology, 2012-2014. Identification and evaluation of structural changes in TFAM gene in neurodegenerative disorders.
Evaluation of mitochondrial anterograde and retrograde signaling in breast cancer
Identification of Molecular Signatures in Patients with High Risk of Developing Ulcerative Colitis Associated Colorectal Neoplasia
SOLS, KMC researchers identify colorectal cancer causing mutations
Researchers from the School of Life Sciences (SOLS) and Kasturba Medical College, Manipal University, have identified cancer causing mutations in long standing ulcerative colitis subjects at risk of progressing into colorectal cancer. They have identified cancer causing mutations in new as well as previously identified oncogenes and tumor suppressor genes. The mutations identified in the study can be used as marker for early diagnosis of ulcerative colitis associated colorectal cancer. The finding of the study is published in Nature Publishing Group journal British Journal of Cancer entitled "Targeted sequencing based analyses of candidate gene variants in ulcerative colitis-associated colorectal neoplasia". SOLS has been working in the field of cancer biomarker discovery, disease modelling and targeted drug delivery for the past several years, says its Director, Dr K. Satyamoorthy. He said: As there is an increased incidence of ulcerative colitis in India due to altered food habits, increased awareness, surveillance and availability of better diagnosis, it is important that early diagnosis of patients who are at risk of developing colorectal cancer is of paramount interest". Dr. Satyamoorthy who also led the investigations said the major challenge in the study was long-period of follow up required to monitor the patients with the ulcerative colitis and reluctance of the patients to undergo colonoscopy. Innovative discoveries such as this can lead to better management of individuals with the disease for early detection and personalized care". While congratulating the researchers Dr. H. Vinod Bhat, Vice Chancellor, Manipal University said the University is supporting molecular genetics programme as there is plenty to discover to the benefit of patients. Manipal University is in unique environment that researchers, clinical practitioners and public health experts can work together to bring about change in the society on how the diseases are managed in individuals". Ulcerative colitis is a chronic inflammatory bowel condition with clinical symptoms of ulceration and bleeding of inner lining of colon. The age of onset for ulcerative colitis varies between 30 to 50 years. Ulcerative colitis subjects with more than seven years of pancolitis or more than 10 years of left sided colitis, experience a higher incidence of colorectal cancer than the rest of the population. Dr. Sanjiban Chakrabarty, lead author of the manuscript said the DNA mutations discovered in the study could distinguish early dysplastic changes in high risk ulcerative colitis and has the potential to predict an adverse outcome." Lead clinical investigator Dr. Ganesh Pai said the results of the studies are important in view of the rising incidence of both ulcerative colitis and colorectal cancer in the Asia Pacific in recent years. The results can help to better understand the development of colorectal cancer in ulcerative colitis, to develop tests for early diagnosis and to possibly select the best treatment strategies for subgroups of patients in the future"