Research

Research

Patents

Patents When: — Where: Category:

Granted Patents 

 

1. An improved process for the preparation of flavonoids from ocimum sanctum (Krishna Tulsi)

 

Indian Patent No. 184300 (1543/DEL/ 1996) granted on 12.06.2001

 

2. Transdermal drug delivery device containing oral antidiabetic drug

 

Indian Patent No 207023 (169/CHE/ 2004) granted on 16.05.2007

 

Investigators: Nayanabhirama Udupa, Srinivas Mutalik

 

Abstract: The invention disclosed in this applications relates to a matrix type transdermal drug delivery system containing an oral antidiabetic drug useful for the treatment of diabetes mellitus, which comprises a matrix of hydrophilic and hydrophobic polymers containing oral antidiabetic drug having coating of an aluminium foil or other backing membrane; the matrix also having coatings of a pressure sensitive adhesive agent and a release liner. This invention also relates to a membrane controlled transdermal drug delivery system containing an oral antidiabetic drug useful for the treatment of diabetes mellitus, which comprises a solution or dispersion or semi-solid mass of a hydrophilic polymer containing an oral antidiabetic drug that is sandwiched between a rate controlling membrane and backing membrane, the rate controlling membrane having a coating of a pressure sensitive adhesive and a release liner. In addition the invention also provides processes for the preparation of above delivery systems.

 

3. Biodegradable polymeric composition for the treatment of diabetes mellitus

 

Indian Patent No 214342 (170/CHE/ 2004) granted on 11.02.2008

 

Investigators: Nayanabhirama Udupa, Srinivas Mutalik  

 

Abstract: The invention disclosed in this application relates to a biodegradable polymeric composition containing an oral antidiabetic drug useful as sustained release drug delivery systems for diabetes mellitus, which comprises a solution of water insoluble biodegradable polymer dissolved in a biocompatible, organic solvent that is dispersible in water or body fluids, and capable of dissipating, diffusing or leaching from the composition into the body fluid upon placement within the body and an oral antidiabetic drug dissolved / dispersed in the said solution. This flowable composition can be stored in a vial or any other mode. In addition the invention also provides processes for the preparation of the above drug delivery systems.

 

4. Mucoadhesive Buccal Composition containing nicotine useful for smoking cessation and a process for its preparation

 

Indian Patent No 221428 (968/CHE/2004) granted on 23.06.2008

 

Investigators: Nayanabhirama Udupa, Shaila Lewis

 

Abstract: The invention disclosed in this application relates to a mucoadhesive buccal composition useful for smoking cessation, which comprises hydrophilic polymers, nicotine, starch and excipients, the excipients having the property of controlling the release of nicotine, the resulting composition being provided with a backing membrane to facilitate unidirectional release of nicotine. This invention also relates to a process for the preparation of the said composition.

 

5. Bioadhesive drug delivery system containing parasympathomimetic agent for the treatment of xerostomia

 

Indian Patent No 222658 (354/CHE/ 2004) granted on 20.08.2008

 

Investigators: Sunil Kumar Agarwal, Ganesa Sundararajan Subramanian, Vidyasagar, Nayanabhirama Udupa, Prakash Shetiya

 

Abstract: Xerostomia is a disease caused by the dryness of mouth due to impaired salivary flow. The invention disclosed in these applications relates to a bioadhesive drug delivery system ! containing parasymphathomimetic agent for the treatment of xerostomia. This bioadhesive drug delivery system useful for the treatment of xerostomia comprises a matrix of hydrophilic polymers containing an parasymphathomimetic agent or its pharmaceutically acceptable salts and comp'ressible pharmaceutically acceptable exepients or their mixtures In addition, the present invention also provides a process for the preparation of the bioadhesive device for the treatment of xerostomia, employing method of granulation and compression.

 

6. Pharmaceutical composition useful for the treatment of diseases caused by viruses and a process for its preparation

 

Indian Patent No 222692 (634/MAS/ 2002) granted on 20.08.2008

 

Investigators: Arun Shirwaikar, Deepti Pandita, Prateek Joshi, Kapileswar Swain

 

Abstract: The invention disclosed in this application relates to a pharmaceutical composition in the form of capsules useful for the treatment of disease caused by viruses such as Hepatitis , AIDS and the like which comprises microspheres of Chitosan incorporating an appropriate antigen encapsulated in enteric coated gelatine capsules The invention also relates to a process for the preparation of the above said composition

 

7. Biodegradable polymeric composition useful in the treatment of periodontitis

 

Indian Patent No 223664 (3/CHE/ 2004) granted on 19.09.2008     

  

Investigators: Nayanabhirama Udupa,  Venkatesh, Sunil Kumar Agarwal, Srinivas Mutalik, Mahalinga Bhat

 

Abstract: The invention disclosed in this application relates to a composition in the form of a gel which is useful for the treatment of periodontal disease, which comprises: (a) a water-insoluble biodegradable polymer (b) a biocompatible organic solvent (c) an active agent (drug) and (d) a co-solvent capable of solubilizing the active agent (drug). The invention also relates to a process for the preparation of the above mentioned composition.

 

8. Biodegradable polymeric monolithic film useful for the restoration of the periodontium

 

Indian Patent No 223665 (4/CHE/ 2004) granted on 19.09.2008  

   

Investigators: Venkatesh, Nayanabhirama Udupa,  Sunil Kumar Agarwal, Srinivas Mutalik, Mahalinga Bhat

 

Abstract: This invention discloses a biodegradable polymeric monolithic film useful for the restoration of peridontium which comprises a glass film lined with aluminium foil, the aluminium foil having a coating of biodegradable polymer in an organic solvent containing an active agent (drug). This invention also discloses a process for the preparation of the above defined biodegradable polymeric monolithic film.

 

9. The compression coated tablet composition for chronotherapy of hypertension

   

Investigators: 286353 (2510/CHE/2010) granted on 16.08.2017

 

Investigators: Usha Y Nayak, N Udupa, Dr P D Gupta

 

Abstract: The present invention related to compression-coated solid pharmaceutical preparation comprising a core tablet containing drug and outer layer made from hydrophilic polymer substance and wicking agent. The timed-release compression-coated tablet composition for oral administration, said composition comprising (i) drug and inactive ingredients in the core tablet, (ii) the outer layer essentially does not contain the drug, instead contains some hydrophilic/hydrophobic polymers and wicking agent. By releasing a drug after a particular lag time, it becomes possible to effectively deliver a drug to a specific site in the digestive tract. It is therefore useful as a timed-release tablet composition for oral administration of a drug that is to be effectively delivered in high concentrations to the definite site in the lower digestive tract, where it will effectively absorbed and is effective for chronotherapy.

Drugs that should be at a particular/higher blood concentration at a specific time period at night or early in the morning are ideal and can be antihypertensive drug preferably angiotensin receptor blockers such as irbesartan, telmisartan, valsartan, losartan etc.

The said polymers may be hydrophilic or hydrophobic. The hydrophilic hydrogel forming polymers may be natural or semi synthetic polymers and it can include guar gum, xanthan gum, polyethylene oxide etc. having a viscosity-average molecular weight of 2,000,000 or higher and/or a viscosity in an aqueous 1% solution (25°C) of 1,000 cps or higher, also can be sodium alginate and which are insoluble in ethyl alcohol. The hydrophobic polymers may be ethyl cellulose.

The composition of the present invention is characterized that a) it absorbs the water in the upper digestive tract so that the outer layer swells and form completely gel, b) the water penetrates through gelled layer to allow complete swelling, once absorbed sufficient water, outer hydrophilic polymer layer starts eroding simultaneously wicking agent forms pores on the polymer layer allowing further erosion, c) the gelled outer layer is eroded as it moves to the lower digestive tract, and d) further, the outer layer is disintegrated partly/fully so that core tablet containing drug is exposed to digestive fluid and release the drug or a) cracks formed on the outer coating layer of the tablet, b) tablet breaks into two halves, c) further, the outer layer is disintegrated fully so that core tablet containing drug is exposed to digestive fluid and release the drug. Ideal timed release of a drug can be realized by this type of design, even in the lower digestive tract with low water content, regardless of the properties of the drug.

The developed formulation delivered the drug at lower intestine thereby enhancing bioavailability of drug and was confirmed by in vivo study in New Zealand white rabbits and healthy human volunteers.