CURRENT ACADEMIC ROLE & RESPONSIBILITIES
- A recognised PhD guide by MAHE
- Teaching Pharmacology to postgraduate and undergraduate students
- Guiding MPharm students in their dissertation work
- Mentoring Postgraduate students for writing projects and applying for grants.
Dr Jayesh Mudgal is an Associate Professor in the Department of Pharmacology.
SUBJECTS CURRENTLY TEACHING
|Pharmacology-2||PHA 405T||IV BPharm|
|Pharmacological and Toxicological Screening methods-I||PHA-MPL 103T||First semester MPharm|
|Advanced Pharmacology-II||PHA-MPL 201T||Second semester MPharm|
|Degree||Specialisation||Institute||Year of passing|
|PhD||Pharmaceutical Sciences||Manipal College of Pharmaceutical Sciences, Manipal University||2013|
|Institution / Organisation||Designation||Role||Tenure|
|Department of Pharmacology, MCOPS||Associate Professor||Teaching and Research||2016 till date|
|Department of Pharmacology, MCOPS||Assistant Professor||Teaching and Research||2013-16|
|Department of Pharmacology, MCOPS||Lecturer||Teaching and Research||2008-13|
|Piramal Life Sciences Ltd (Previously known as Nicholas Piramal Research Centre), Mumbai, India||Research Associate||Planning, designing and execution of project work in different therapeutic areas such as inflammation, pain, diabetes, obesity and epilepsy||2007-2008|
AREAS OF INTEREST, EXPERTISE AND RESEARCH
Area of Interest
Teaching Human Anatomy & Physiology, Pharmacology and pursuing research in the field of health sciences
Area of Expertise
As an academician: Teaching Pharmacology, Human Anatomy & Physiology. As a researcher: Animal model development for translational research, Standardisation of analytical techniques, Pharmacokinetic studies in biological samples, Assay development and standardisation
Area of Research
Pharmacology, Toxicology, Cellular and molecular biology, Preclinical drug discovery in the field of therapeutic areas such inflammation, pain, metabolic, neurological and oncological disorders
Professional Affiliations & Contributions
- Life member of Association of Pharmaceutical Teachers of India.
- Life member of Indian Pharmacology Society.
- Life member of Association of Community Pharmacists of India.
|Piramal Life Sciences Ltd (Previously known as Nicholas Piramal Research Centre), Mumbai, India||Designation: Research Associate Role: • Planning, designing and execution of project work in different therapeutic areas such as inflammation, pain, diabetes, obesity, epilepsy etc. • Documentation of work and writing research papers • Making monthly and annual progress reports and their timely submission / presentation|
Total number of publications: 41
Few important research papers are listed below. For more papers, kindly browse the following link- https://manipal.pure.elsevier.com/en/persons/jayesh-mudgal
Impact of caffeic acid on aluminium chloride-induced dementia in rats
2013, Journal of Pharmacy and Pharmacology, Royal Pharmaceutical Society of Great Britain, Royal Pharmaceutical Society of Great Britain, 65, 1745-1752.
Sesamol treatment reduces plasma cholesterol and triacylglycerol levels in mouse models of acute and chronic hyperlipidemia
2013, Lipids, SpringerLink, NY, USA.
High carbohydrate diet with 30% sucrose solution: an optimised rodent model for simulating human insulin resistance
2013-01-01 AS Theerthahalli RR Shenoy PG Nayak N Kumar
2013, Pharmacologia, 4, 157-163.
Antidiabetic, antihyperlipidemic and antioxidant effects of the flavonoid rich fraction of Pilea microphylla (L) in high fat diet/streptozotocin-induced diabetes in mice
2012-01-01 P Bansal P Paul MK Unnikrishnan KI Priyadarsini
2012, Expermental and Toxicologic Pathology, Elsevier, 64, 651-658.
NO-NSAIDs. Part 3: nitric oxide-releasing pro-drugs of non-steroidal anti-inﬂammatory drugs
2012-01-01 Namdev Borhade Manoj Karwa Mini Dhiman Machhindra Gund
2012, Chemical and Pharmaceutical Bulletin, J-STAGE, Japan, 60, 465–481.
Ameliorative effect of caffeic acid against inflammatory pain in rodents
2011-01-01 A Mehrotra R Shanbhag MR Chamallamudi (Professor) VP Singh
2011, European Journal of Pharmacology, Elsevier, 666, 80-86.
Antioxidant, anti-inflammatory and anti-hyperglycaemic activities of heterocyclic homoprostanoid derivatives
2011, Bioorganic and Medicinal Chemistry, Elsevier, 19, 384-392.
Anti-inflammatory activity of terminalia paniculata bark extract against acute and chronic inflammation in rats
2011-01-01 S Talwar PG Nayak P Bansal K Nandakumar
2011, Journal of Ethnopharmacology, Elsevier, 134, 323-328.
Anti-tubercular activity of synthesized novel 2,5-disubstituted-1,3,4-oxadiazole derivatives
Indian Drugs 2015; 52:40-44
Sesamol, a lipid lowering agent, ameliorates aluminium chloride induced behavioral and biochemical alterations in rats
Jessy John Madhavan Nampoothiri Nitesh Kumar Jayesh Mudgal Gopalan Kutty Nampurath Mallikarjuna Rao Chamallamudi
Pharmacogn Mag. 2015;11:327-36
Modulatory Role of Simvastatin against Aluminium Chloride-Induced Behavioural and Biochemical Changes in Rats
Madhavan Nampoothiri Jessy John Nitesh Kumar Jayesh Mudgal Gopalan Kutty Nampurath Mallikarjuna Rao Chamallamudi
Behav Neurol. 2015, doi: 10.1155/2015/210169
Novel 2,5-disubstituted-1,3,4-oxadiazoles as anti-inflammatory drugs
Ega Durgashivaprasad Geetha Mathew Sarine Sebastian Manohar Reddy S.A Jayesh Mudgal Gopalan Kutty Nampurath
Ind J Pharmacol. VOL. 46 | Issue 5 | September-October 2014, 521-26
Synthesis, characterization, and preclinical evaluation of new thiazolidin-4-ones substituted with p-chlorophenoxy acetic acid and clofibric acid against insulin resistance and metabolic disorder
Vasantharaju S. Gowda Jayesh Mudgal Punit Bansal Pawan G. Nayak Seethappa A Manohara Reddy Gautham G. Shenoy Manna Valiathan Mallikarjuna R. Chamallamudi Gopalan K. Nampurath
Biomed Res Int. 2014, doi: 10.1155/2014/620434
Remedial effects of novel 2,3-disubstituted thiazolidin-4-ones in chemical mediated inflammation
Jayesh Mudgal Vasantharaju S Gowda Geetha Mathew Pawan G. Nayak Nitin D. Reddy Neelesh Namdeo Ravilla R. Kumar Chaitanya Kantamaneni Mallikarjuna R. Chamallamudi Gopalan K. Nampurath
Chemico-biological interactions, 210 (2014) 34-42
Preclinical efficacy of a gastro-sparing novel thiazolidin-4-one in alleviating secondary lesions of polyarthritis: A multi-parametric approach
Eur. J. Pharm. Sci., 91 (2016) 74-83. (Impact factor: 3.77 as per JCR 2015)
Dose-related antihyperglycemic and hypolipidemic effects of two novel thiazolidin-4-ones in a rodent model of metabolic syndrome.
Karot, S.S Surenahalli, V.G Kishore, A Mudgal, J Nandakumar, K Chirayil, M.T Mathew, G Nampurath, G. K
Journal of Diabetes (2016), In Press (Impact factor: 2.55, JCR 2015)
Endothelium dependent and independent mechanisms of vasorelaxant activity of synthesized 2,5-disubstituted-1,3,4-oxadiazole derivatives in rat thoracic aorta-ex vivo and molecular docking studies
Letters in Drug Design and Discovery., 13 (2016) 441-450. (Impact factor: 0.77)
In vivo Evaluation of Two Thiazolidin-4-one Derivatives in High Sucrose Diet Fed Pre-diabetic Mice and Their Modulatory Effect on AMPK, Akt and p38 MAP Kinase in L6 Cells
Front Pharmacol. 2016 Oct 14;7:381
Extraction, characterization and evaluation of Kaempferia galanga L. (Zingiberaceae) rhizome extracts against acute and chronic inflammation in rats
J Ethnopharmacol. 2016 Oct 5. pii: S0378-8741(16)31155-2. doi: 10.1016/j.jep.2016.10.010. [Epub ahead of print]
Caffeic acid attenuates lipopolysaccharide-induced sickness behaviour and neuroinflammation in mice
Neurosci Lett. 2016 Oct 6;632:218-23. doi: 10.1016/j.neulet.2016.08.044
Neprilysin, the kidney brush border neutral proteinase: a possible potential target for ischemic renal injury
Toxicology mechanisms and methods 30 (2), 88-99, 2020
Effect of coffee constituents, caffeine and caffeic acid on anxiety and lipopolysaccharide-induced sickness behavior in mice
Journal of Functional Foods 64, 103638, 2020
Possible involvement of metformin in downregulation of neuroinflammation and associated behavioural changes in mice
Inflammopharmacology 27 (5), 941-948, 2019
Improved in vitro and in vivo hepatoprotective effects of liposomal silymarin in alcohol-induced hepatotoxicity in Wistar rats
Pharmacological Reports 71 (4), 703-712, 2019
Neuromodulatory potential of phenylpropanoids; para-methoxycinnamic acid and ethyl-p-methoxycinnamate on aluminum-induced memory deficit in rats
Toxicology mechanisms and methods 29 (5), 334-343, 2019
Cannabinoid receptor 2 activation mitigates lipopolysaccharide-induced neuroinflammation and sickness behavior in mice
Psychopharmacology 236 (6), 1829-1838, 2019
Exploring the potential of Desmodium gangeticum (L.) DC. extract against spatial memory deficit in rats
Pharmacognosy Magazine 15 (62), 78, 2019
Immunomodulatory role of chitosan‐based nanoparticles and oligosaccharides in cyclophosphamide‐treated mice
Scandinavian journal of immunology 89 (4), e12749, 2019
InCl3 mediated heteroarylation of indoles and their derivatization via CeH activation strategy: Discovery of 2-(1H-indol-3 yl)-quinoxaline derivatives as a new class of PDE4B
European Journal of Medicinal Chemistry 174, 198-125, 2019
Effect of Caffeic Acid on Ischemia-Reperfusion-Induced Acute Renal Failure in Rats
Pharmacology 103 (5-6), 315-319, 2019
Dietary oils ameliorate aluminum chloride-induced memory deficit in wistar rats
Pharmacognosy Magazine 15 (60), 36, 2019
Evaluation of anticancer activity of hydroxycinnamic acid derivatives against lung cancer
The project work is focused on identifying the potential of hydroxycinnamic acid derivatives against lung cancer.
Dose dependent study of caffeic acid against inflammation and pain
2013-01-01 Ravilla Ravi Kumar (PG)
The project was aimed at the exploration of possible dose-dependent effect of caffeic acid on chronic inflammatory disorder. The project revealed the molecular mechanism of caffeic acid in amelioration of arthritis.
Evaluation of antioxidant, anticancer, anti- angiogenic and anti-inflammatory activities of the leaves of Manihot esculenta Crantz
2012-01-01 Magith Thambi (PG)
The project evaluated the aqueous and alcoholic extracts of Manihot esculenta Crantz (Euphorbiaceae) for antioxidant, anticancer, anti-angiogenic and anti-inflammatory activities using various in vitro models.
Neuro-inflammation in Alzheimer’s disease and role of caffeic acid and its derivative against aluminium chloride-induced dementia in rats
2011-01-01 Kafeel A Khan (PG)
The project described the effect of caffeic acid and p-coumaric acid against aluminium chloride-induced dementia in rats. Further, role of leukotriene receptor antagonist was studied in dementia.
A study to investigate a hypothesis that the PLGA-Nanoparticulate-Diclofenac delivers high amounts of diclofenac to the inflammatory sites
The project was designed to develop a formulation of diclofenac sodium to target the local inflammatory site for minimising the side effects associated with chronic systemic exposure of diclofenac [2014-2015]