ABSTRACT Background: Hypertrophic cardiomyopathy (HCM), an auto-somal dominant disorder due to mutation of genes encoding sarcomeric proteins, leads to left ventricular diastolic dysfunction. Recently, the research in this area suggests that systolic dysfunction exists in the patients with HCM even though traditional measures of systolic dysfunction are normal. So, we carried out this study to determine global systolic dysfunction in patients with HCM. Materials and Methods: A total of 18 patients, diagnosed with HCM according to echocardiography parameters, that is thickness of interventricular septum/posterior wall thickness >1.3 or hypertrophy involving apex only with or without left ventricular outflow tract obstruction, were included in the study and were compared with normal age-matched controls. We measured torsion and strain imaging by 2-dimensional echocardiography as well as strain imaging by tissue Doppler echocardiography. Result: The results of the study showed that there was considerable increased torsion in patients with HCM as compared to normal subjects (16.61±7.43 vs. 10.42±4.73, p=0.006). Tissue Doppler indices—systolic annular velocity (7.7±0.7 vs. 8.7±1.00, p=0.012) and lateral wall E/E’ (12.52±5.27 vs. 6.66±1.67, p<0.001) were significantly different in patients with HCM and normal subjects. The average systolic strain and strain rate as well as diastolic strain rate were significantly different in both the groups when strain imaging was performed by tissue Doppler echocardiography. We also observed significantly reduced global longitudinal, circumferential and radial strain in patients with HCM when strain analysis was carried out with 2-dimensional speckle tracking echocardiography. Conclusion: The global subtle systolic dysfunction, as measured by left ventricular torsion and strain imaging, is present in patients with HCM even though traditional measure of systolic dysfunction is normal. Journal of Clinical and Diagnostic Research. 2014 Dec, Vol-8(12): MC05-MC09:DOI:10.7860/JCDR/2014/10185.5287

ABSTRACT Patients with diabetes mellitus (DM) are prone to develop heart failure even in the absence of evident hypertension and coronary artery disease. This entity is difficult to detect in early stages by conventional echocardiographic techniques. 32 asymptomatic TMT (tread mill stress test) negative DM patients compared with control subjects were screened and performed LV (left ventricle) strain, strain rate and tissue Doppler imaging. Tissue Doppler imaging revealed increased E/E’ of IVS (Inter ventricular septum) (p value<0.001) among DM suggestive of diastolic dysfunction. The tissue velocities E’ of both the LV lateral wall (p value=0.004) and RV (right ventricle) (p value =0.003) were reduced among DM. Similarly, the peak systolic strain (p value<0.001), and strain rate (p value<0.001) were significantly reduced among diabetic subjects. DM is an independent risk factor for myocardial dysfunction even in asymptomatic normotensive subjects. The changes that occur in the myocardium due to diabetic cardiomyopathy can be detected early, as the novel tissue Doppler is a noninvasive technique for early detection of Diabetic cardiomyopathy. Research Journal of Pharmaceutical, Biological and Chemical Sciences

ABSTRACT Background and Aims: Dynamic parameters such as the respiratory variation in aortic flow peak velocity (ΔVpeak) and inferior vena cava distensibility index (dIVC) are accurate indices of fluid responsiveness in adults. Little is known about their utility in children. We studied the ability of these indices to predict fluid responsiveness in anaesthetised and mechanically ventilated children. Methods: This prospective study was conducted in 42 children aged between one to 14 years scheduled for elective surgery under general endotracheal anaesthesia. Mechanical ventilation was initiated with a tidal volume of 10 ml/kg. ΔVpeak, dIVC and stroke volume index (SVI) were measured before and after volume expansion (VE) with 10 ml/kg of crystalloid using transthoracic echocardiography. Patients were considered to be responders (R) and non‑responders (NR) when SVI increased to either ≥15% or <15% after VE. ΔVpeak and dIVC were analysed between R and NR. Results: The best cut‑off value for ΔVpeak as defined by the receiver operator characteristics (ROC) curve analysis was 12.2%, for which sensitivity, specificity, positive predictive value and negative predictive value were 100%, 94%, 96% and 100%, respectively, the area under the curve was 0.975. The best cut‑off value for dIVC as defined by the ROC curve analysis was 23.5%, for which sensitivity, specificity, positive predictive value and negative predictive value were 91%, 89%, 91% and 89%, respectively, the area under the curve was 0.95. Conclusion: ΔVpeak and dIVC are reliable indices of fluid responsiveness in children. Indian journal of anaesthesia: Vol 60 / Issue 2/ February 2016 Website: www.ijaweb.org DOI: 10.4103/0019-5049.176285

Description: A 53-year-old woman diagnosed with rheumatic mitral stenosis (at the age of 40 years) presented with worsening dyspnoea New York Heart Association class III of 1 month duration ECG showed atrial fibrillation with a fast ventricular rate. Echocardiography parameters were suggestive of severe mitral stenosis with atrial fibrillation. Transesophageal echocardiography (TEE) showed a large clot in the left atrial (LA) appendage, attached to the LA roof and traversing towards the opposite wall A left atrial (LA) clot in the presence of mitral valve disease is often focal in most cases. The present case had a huge non-focal clot confined to a plane of the LA body, partitioning the LA into two separate cavities, the rarest of its kind. BMJ (British Medical Journal)

Citation : Krishnananda N1*, Ranjan Shetty K2 , Pratap Kumar3 , Kiran Shetty4 , Sridevi Prabhu5 , Jyothi S 6; “Congenital Mitral Atresia: A Rare Anomaly Diagnosed in Fetal Echocardiography: A Case Study” Research Journal of Pharmaceutical, Biological and Chemical Sciences, 7(5), September – October 2016, Page No. 2506- 1939 URL: http://www.rjpbcs.com/7(5)/September – October 2016

Citation: Farooq Syed1, Leslie Edward S Lewis2, Ramesh Bhatt Y3, Jyothi Samanth4, and Kiran Shetty5; “Intracardiac Fungal Ball in A Preterm Newborn with Congenital Heart Disease Complicated by Right Atrial Mycetoma Obstructing Tricuspid Valve”, Research Journal of Pharmaceutical, Biological and Chemical Sciences, 7(5), September – October 2016, Page No. 2506-2509 URL: http://www.rjpbcs.com/7(5)/September – October 2016

KCitation: Krishnananda N, Pratap Kumar3, Ranjan Shetty, Kiran Shetty, Jyothi S, Shreemathi S Mayya, Arun G Maiya, ‘’Prediction of Intrauterine Growth Restriction (IUGR) using Novel Method of Noninvasive Doppler Ultrasound - A Systematic Review’’, Int. J. Pharm. Sci. Rev. Res., 41(1), November - December 2016; Article No. 26, Pages: 132-137 URL: Int. J. Pharm. Sci. Rev. Res., 41(1), November - December 2016; Article No. 26, Pages: 132-137 URL: Int. J. Pharm. Sci. Rev. Res., 41(1), November - December 2016; Article No. 26, Pages: 132-137

Citation: Mathew et al,http://dx.doi.org/10.22159/ajpcr.2016.v9i6.14677 URL: http://dx.doi.org/10.22159/ajpcr.2016.v9i6.14677

Citation: U. Raghavendral, U. Rajendra Acharya, Anjan Gudigarl, Ranjan Shetty N, Krishnananda, Umesh pai, Jyothi Samanth, Chaithra Nayak; ‘’ Automated screening of congestive heart failure using variational mode decomposition and texture features extracted from ultrasound images’’ Neural comput & applic DOI 10.1007/s00521-017-2839-5 URL: http://link.springer.com/article/10.1007/s00521-017-2839-5

Citation: Nayak K et al; DOI: http://dx.doi.org/10.22159/ajpcr.2017.v10i3.16422 URL: http://dx.doi.org/10.22159/ajpcr.2017.v10i3.16422

Citation: Shetty R, Samant J, Nayak K, Maiya M, Reddy S. Feasibility of telecardiology solution to connect rural health clinics to a teaching hospital. Indian J Community Med 2017;42:170-3 URL: http://www.ijcm.org.in/text.asp?2017/42/3/170/212066

Citation: Jyothi Samanth et al; Use of tissue doppler imaging to detect right ventricular myocardial dysfunction in patients with chronic obstructive pulmonary disease; Asian J Pharm Clin Res, Vol 10, Issue 6, 2017, 118-124 URL: http://dx.doi.org/10.22159/ajpcr.2017.v10i6.17517

Citation: Kiran Shetty et al; Comparison of Plasma Levels of Renin, Vasopressin and Atrial Natriuretic Peptide in Hypertensive Amlodipine Induced Pedal Oedema, Non-Oedema and Cilnidipine Treated Patients; Journal of Clinical and Diagnostic Research. 2017 June, Vol-11(6): FC05-FC08; DOI: 10.7860/JCDR/2017/25097.9958 URL: http://dx.doi.org/10.7860/JCDR/2017/25097.9958

Citation: Jagruti Balde et al; Echocardiographic abnormalities in cirrhosis & their correlation with severity of cirrhosis using Child-Pugh score among patients in a tertiary care hospital; Indian J Med Res 144, December 2016, DOI: 10.4103/ijmr.IJMR_1486_15 URL: http://dx.doi.org/10.4103/ijmr.IJMR_1486_15

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Role: Co-guide