DESCRIPTION: A 40-year-old lady was admitted with a week’s history of fever and dyspnoea. Transthoracic echocardiography revealed 0.5 × 0.5 cm vegetation on the posterior mitral leaflet with a severe eccentric mitral regurgitation (MR) hugging the left atrial aspect of anterior mitral leaflet and the interatrial septum (IAS) which was confirmed by a transoesophageal echocardiogram BMJ Case Reports 2011;10.1136/bcr.03.2011.3993

DESCRIPTION: Pericardial cysts are rare benign mediastinal masses usually detected in asymptomatic individuals. Rare complications include compression of the bronchi, ventricular outflow tract, rupture with tamponade and sudden death. Treatment in symptomatic individuals includes surgical resection or percutaneous aspiration. BMJ Case Reports 2012;10.1136/bcr-03-2012-5984,

Description: Ebstein’s anomaly, a rare congenital cardiac malformation, is associated with a worse prognosis when it presents early as heart failure in the fetus and neonate. ▸ Targeted fetal echocardiography helps in risk stratification of such high-risk pregnancies towards more aggressive management. BMJ Case Reports 2012;10.1136/bcr-2012-006446,

Abstract: Techniques of implanting pacing leads in the right ventricle (RV) have evolved over time and involve the use of preshaped stylets. However, in the presence of venous abnormalities, it could be very challenging to do the same. We describe two cases with complex superior vena caval (SVC) anatomy which could be negotiated only with the use of a slittable coronary sinus guiding sheath and successful placement of pacing lead in the right ventricle. BMJ Case Reports 2012;10.1136/bcr-2012-007687

Abstract: Carotid artery stenosis is a disabling disease in all age groups. Elderly people are more prone to recurrent strokes due to advancing age and multiple co-morbidities. Treatment options for symptomatic carotid stenosis in the very elderly are the same as in younger patients although with a higher operative risk. We describe a successful case of carotid artery stenting in a nonagenarian with symptomatic carotid artery stenosis, a subgroup for whom treatment options are rarely discussed in guidelines Australas Med J. 2012; 5(10): 528–530. doi: 10.4066/AMJ.2012.1278

Abstract OBJECTIVE:The purpose of this study was to examine the safety and efficacy of the Frontrunner XP CTO (chronic total occlusion) catheter (Cordis Corporation) for recanalization of CTO of femoropopliteal arteries. METHODS:A retrospective analysis of consecutive patients with critical limb ischemia (CLI) who underwent femoropopliteal angioplasty for TransAtlantic Inter-Society Consensus (TASC) class D lesions between 2009 and 2011 was performed. Twenty-two patients were enrolled with a mean age of 58.9 ± 11.5 years. Patients were enrolled with totally occluded arteries (mean occlusion length, 18.0 ± 10.1 cm) that were treated with the Frontrunner XP CTO catheter. All lesions were complex (TASC D) and 86.4% of the lesions were mildly calcified. A Frontrunner catheter was used to treat 22 CTOs after guidewire failure. RESULTS:Twenty-two of the 33 cases (66.7%) had failed previous attempts of percutaneous intervention with conventional guidewire. The Frontrunner catheter was used to treat 22 CTOs after guidewire failure. The Frontrunner catheter successfully facilitated the placement of a guidewire into the distal true lumen in 21 cases (95.5%). Thrombolysis in Myocardial Infarction 3 flow was achieved in all target vessels after further balloon angioplasty or stenting. CONCLUSIONS:The Frontrunner XP CTO catheter is safe and effective for successful recanalization of CTO of femoropopliteal arteries and it should be an alternative method after guidewire failure. J Invasive Cardiol. 2013 Jul;25(7):344-7

Abstract: Coronary Artery Disease (CAD), caused by the buildup of plaque on the inside of the coronary arteries, has a high mortality rate. To efficiently detect this condition from echocardiography images, with lesser inter-observer variability and visual interpretation errors, computer based data mining techniques may be exploited. We have developed and presented one such technique in this paper for the classification of normal and CAD affected cases. A multitude of grayscale features (fractal dimension, entropies based on the higher order spectra, features based on image texture and local binary patterns, and wavelet based features) were extracted from echocardiography images belonging to a huge database of 400 normal cases and 400 CAD patients. Only the features that had good discriminating capability were selected using t-test. Several combinations of the resultant significant features were used to evaluate many supervised classifiers to find the combination that presents a good accuracy. We observed that the Gaussian Mixture Model (GMM) classifier trained with a feature subset made up of nine significant features presented the highest accuracy, sensitivity, specificity, and positive predictive value of 100%. We have also developed a novel, highly discriminative HeartIndex, which is a single number that is calculated from the combination of the features, in order to objectively classify the images from either of the two classes. Such an index allows for an easier implementation of the technique for automated CAD detection in the computers in hospitals and clinics. Computer Methods and Programs in Biomedicine Elsevier: Volume 112, Issue 3, December 2013, Pages 624–632

Abstract: Aims: Patients with severe sepsis and septic shock often exhibit significant cardiovascular dysfunction. We designed the study with an aim to determine the severity of cardiac dysfunction in the different group of sepsis patients. Study Design: Single-center, cross-sectional study Place and Duration of Study: The study was carried out at Department of Cardiology, Kasturba Medical College and Hospital, Manipal from June 2011 to December 2012. Methodology: A total of 74 patients who were diagnosed with sepsis were enrolled in the study. All patients were subjected to routine analysis, laboratory test and echocardiogrphic assessment. Results: The patients were divided into 3 groups: sepsis group (n = 11), severe sepsis group (n = 37) and septic shock group (n = 26). The mitral E/A value is significantly higher in patients with septic shock than that of the patients with sepsis (P = 0.04). The indices of right ventricular dysfunction did not show any significant difference in the patients with septic shock and that of sepsis. Conclusion: Left ventricular dysfunction may be considered prevalent in sepsis as per the significant E/A values. However, the other echocardiographic parameter should also be considered. This may even infer that cardiac dysfunction may not correlate with the severity of sepsis. British Journal of Medicine and Medical Research, ISSN: 2231-0614,Vol.: 5, Issue

Description: Coronary artery anomalies, though rare, are extensively classified and categorized. The overall incidence of coronary artery anomalies is about 1% in the general population. Single coronary artery and its variants account for approximately 0.024% in the general population. Journal of Cardiovascular Disease Research 4 (2013) 74–75

J Clinical and Diagnostic Research. 2013 Sep; 7(9): 1959–1963. Published online 2013 Sep 10. doi: 10.7860/JCDR/2013/5915.3369

Description: In normal participants, the left anterior descending (LAD) artery arises from the left coronary artery (LCA) and courses along the anterior interventricular sulcus (AIVS) until it reaches the apex. Dual LAD circulation is an uncommon coronary anomaly in which there are two LAD arteries. A type 4 dual LAD circulation is an extremely rare variant of a dual LAD in which one of the LAD arteries arises from the right coronary artery (RCA). BMJ Case Reports 2014; doi:10.1136/bcr-2014-205053

Aims: Durable polymers used for first-generation drug-eluting stents (DES) potentially contribute to persistent inflammation and late stent thrombosis. The Supraflex (Sahajanand Medical Technologies Pvt. Ltd., India) is a cobalt-chromium, balloon-expandable DES system that incorporates an ultra-thin strut thickness (60µm), a biabsorbable polymer and sirolimus. The aim of the MANIPAL-FLEX first-in-man (FIM) study was to assess the safety and efficacy of the Supraflex sirolimus-eluting stent (SES) implantation, in de novo coronary artery disease (CAD), using clinical and quantitative coronary angiography (QCA) follow-ups

Citation :Vamsi Krishna Kamana, Padmakumar Ramachandran, Umesh Pai, M., Ravella Keerthika Chowdary and Sridevi Prabhu 2016. “Aortic bifurcation stenting with two self-expanding stents for severely diseased iliac arteries’’ International Journal of Current Research 8, (07), 34383-34386. URL: http://www.journalcra.com//Vol. 8, Issue, 07, pp.34383-34386, July, 2016

Citation :Vamsi Krishna Kamana, Padmakumar Ramachandran, Umesh Pai, M., Sridevi Prabhu and Ravella Keerthika Chowdary 2016. “A case of ataxic hemi paresis treated by successful subclavian artery stenting’’ International Journal of Current Research, 8, (07), 34342-34344. URL: http://www.journalcra.com// Vol. 8, Issue, 07, pp.34342-34344, July, 2016

Citation : Ashwal Adamane Jayaram et al., All That Glitters Is Not Gold: All Unilateral Oedema Is Not DVT, Journal of Clinical and Diagnostic Research. 2016 Jul, Vol-10(7): OD10-OD11 URL: www.jcdr.net//Journal of Clinical and Diagnostic Research. 2016 Jul, Vol-10(7): OD10-OD11

Citation :Vamsi Krishna Kamana, Padmakumar Ramachandran, Ashwal A. J, Sumith Aggarwal and Umesh Pai, M, 2016. “Balloon angioplasty for an unusual cause of bilateral brachial artery occlusion: a rare manifestation of fibro muscular dysplasia’’ International Journal of Current Research, 8, (05), 31951-31954. URL: http://www.journalcra.com// Vol. 8, Issue, 05, pp.31951-31954, May, 2016

Citation : Vamsi Krishna kamana, Anand M. Krishnan, Ravella Keerthika Choudary and Umesh Pai, 2016, ‘’ Atypical presentation and coronary angiogram of a case of Vasospastic angina”, International Journal of Current Research, 8, (03), 28645-28648. URL: http://www.journalcra.com// Vol. 8, Issue, 03, pp. 28645-28648, March, 2016

Citation: Kiran Shetty, Ranjan Shetty, Naveen Chandra GS, Umesh Pai, Amruth Kiran, Mohan NK; ‘’ Bee Alert! Multiple Honey Bee Stings Lead to Heart Attack: A Case Report’’; Int. J. Pharm. Sci. Rev. Res., 41(2), November - December 2016; Article No. 18, Pages: 83-85 URL: Int. J. Pharm. Sci. Rev. Res., 41(2), November - December 2016; Article No. 18, Pages: 83-85

Citation: Ranjan Shetty, Jayesh Prajapati, Umesh Pai, and Kiran Shetty; ‘’ Preliminary Evaluation of Clinical and Angiographic Outcomes with Biodegradable Polymer Coated Sirolimus-Eluting Stent in De Novo Coronary Artery Disease: Results of the MANIPAL-FLEX Study’’; Hindawi Publishing Corporation, Scientifica Volume 2016, Article ID 9324279, 8 pages URL: http://dx.doi.org/10.1155/2016/9324279

Citation: Vamsi Krishna kamana, Padmakumar Ramachandran, Anand Muthu Krishnan, Ravella Keerthika Chowdary, Umesh Pai Malpe; ‘’ Aomalous Single Coronary Artery Presenting with Acute Myocardial Infarction’’ Journal of Clinical and Diagnostic Research. 2016 Dec, Vol-10(12): OD01-OD02, DOI: 10.7860/JCDR/2016/20599.8977 URL: Vamsi Krishna kamana et al., Anomalous Origin of the Entire Coronary System from the Right Coronary Ostia Presented as Acute Coronary Syndrome, 2016 Dec, Vol-10(12): OD01-OD02, DOI: 10.7860/JCDR/2016/20599.8977

Citation: U. Raghavendral, U. Rajendra Acharya, Anjan Gudigarl, Ranjan Shetty N, Krishnananda, Umesh pai, Jyothi Samanth, Chaithra Nayak; ‘’ Automated screening of congestive heart failure using variational mode decomposition and texture features extracted from ultrasound images’’ Neural comput & applic DOI 10.1007/s00521-017-2839-5 URL: http://link.springer.com/article/10.1007/s00521-017-2839-5

Citation: Kiran Shetty et al; Comparison of Plasma Levels of Renin, Vasopressin and Atrial Natriuretic Peptide in Hypertensive Amlodipine Induced Pedal Oedema, Non-Oedema and Cilnidipine Treated Patients; Journal of Clinical and Diagnostic Research. 2017 June, Vol-11(6): FC05-FC08; DOI: 10.7860/JCDR/2017/25097.9958 URL: http://dx.doi.org/10.7860/JCDR/2017/25097.9958

Citation: Ashwal A Jayaram et al., Feasibility of Sinus Rhythm in Rheumatic Mitral Stenosis; Journal of Clinical and Diagnostic Research. 2017 Feb, Vol-11(2): OC01-OC05 URL: Journal of Clinical and Diagnostic Research. DOI:10.7860/JCDR/2017/19382.91242017 Feb, Vol-11(2): OC01-OC05

The study was performed to find the clinical profile and outcomes in patients undergoing IVC filter placement.

Description: Although Coronary artery disease being one of the commonest cause of LV dysfunction, a subgroup can still be having normal epicardial coronaries. This study was designed to find the overall incidence of CAD in patients with Left ventricular dysfunction.

Description: The study was aimed to find the complications associated with intervention in bifurcation coronary lesions, to find the incidence of compromise of side branch when main branch stented alone.

Description: This study was carried out to find out radiation exposure and contrast usage in patients undergoing different cardiac interventions

The study aimed to identify the post intervention clinical profile of the peripheral vascular disease patients.

AThe study was performed to compare the radiographic parameters between two cardiac catheterization lab in KMC hospital, Manipal

Clinical profile of patients with history of myocardial infraction and raised hs-CRP levels.

The study related to the assessment of subtle cardiac dysfunction using echocardiography in patients undergoing Applications of tissue Doppler and speckle tracking echocardiography in the early detection of diastolic dysfunction in cancer patients undergoing anthracycline based chemotherapy.

This study aimed to find the lesion characteristics in patients with ACS and Chronic stable angina in patients using IVUS

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Role: Co-Guide

Role: Co-guide

Role: Guide

Role: Co-guide

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