Dr. Upasana Kachroo

Associate Professor

Department of Physiology

Qualification: Degree: MD Specialization: Physiology

CURRENT ACADEMIC ROLE & RESPONSIBILITIES

    • Theory and practical sessions for I MBBS students and MSc. Candidates
    • Resource faculty in Medical Education Department

SUBJECTS CURRENTLY TEACHING

Subject Semester / Year
Physiology M.B.B.S
Physiology M.D. Physiology

ACADEMIC QUALIFICATIONS

Degree Specialisation Institute Year of passing
M.D. Physiology M.D. Physiology Christian Medical College, Vellore May 2015
MBBS MBBS Mysore medical College & Research Institute February 2009

Experience

Institution / Organisation Designation Role Tenure
Kasturba Medical College Manipal Associate Professor 15.11.2021-Till date
Christian Medical College, Vellore Assistant Professor 12.06.2015-14.11.2021
Christian Medical College, Vellore Senior Resident 30.05.2015-11.06.2015

Comparison of Electrophysiological properties and gene expression between human cartilage-derived chondroprogenitors and chondrocytes from normal and osteoarthritic cartilage

Co-Investigator

To compare chondrocytes and chondroprogenitors for superiority in producing genuine hyaline cartilage for cell-based therapy in cartilage repair and regeneration Funding agency: AO-Trauma grant 2017

To compare the repair of chondral defects using human bone marrow mesenchymal stem cells, articular cartilage derived chondrocytes, cell sorted chondroprogenitors and fibronectin adhesion derived chondroprogenitors suspended in platelet rich plasma, in a human osteochondral unit model implanted in NSG-SCID mice.

Co-Investigator 

To compare various cell types as contenders for cell-based therapy in cartilage repair by using multiple assessment parameters to judge repair tissue quality in a translatable mode by using human osteochondral units finally implanted in NSG-SCID mice Funding agency: DBT grant 2020

AREAS OF INTEREST, EXPERTISE AND RESEARCH

Area of Interest

1. Teaching physiological concepts especially in the small group/practical setting or self-directed sessions

Area of Expertise

Patch clamp (Cellular electrophysiology); Cell culture; Molecular biology: Flowcytometry, RT-PCR etc; .Immuno-histo/cyto chemistry; Animal tissue/model studies; Botanical extraction; Autonomic Function testing (HRV)

Area of Research

Cartilage repair and regeneration b. Electrophysiological profiling and comparison using Patch clamp technique. c. Heart Rate Variability (HRV) indices: underlying circuitry and applications d. Botanical extraction: understanding therapeutic and toxic effects of plant derivatives. e. Medical Education: advances, animations, and models

Professional Affiliations & Contributions

  • Life member of the association of physiologists of Tamil Nadu
  • Life member of the association of physiologists and pharmacologists of India
  • Life member of Indian Cartilage Society
  • Reviewer for peer-reviewed journals: Journal of Clinical Orthopaedics and Trauma, Biotechnic and Histochemistry, Connective Tissue Research, European Journal of Inflammation, JoVE, and Gene

Comparison of Electrophysiological Properties and Gene Expression between Human Chondrocytes and Chondroprogenitors Derived from Normal and Osteoarthritic Cartilage

2020 Jul Kachroo U Livingston A Vinod E Sathishkumar S Boopalan PRJVC

Cartilage. ;11(3):374–84.

Evaluation of CD49e as a distinguishing marker for human articular cartilage derived chondroprogenitors

2020 Jun Kachroo U Ramasamy B Vinod E

The Knee. ;27(3):833–7.

Comparison of Human Platelet Lysate versus Fetal Bovine Serum for Expansion of Human Articular Cartilage-Derived Chondroprogenitors

Kachroo U Zachariah SM Thambaiah A Tabasum A Livingston A Rebekah G

Cartilage. 2020 May 14;

An electrophysiological comparison of freshly isolated caprine articular chondrocytes versus cryopreserved chondrocytes

2020 Kachroo U Kanthakumar P

Indian J Physiol Pharmacol. ;64(3):181–7.

Red cell indexes made easy using an interactive animation: do students and their scores concur?

Kachroo U Vinod E Balasubramanian S Prince N

Adv Physiol Educ. 2018 Mar 1;42(1):50–5