Dr Jayesh Mudgal

Associate Professor

Department of Pharmacology


    Dr Jayesh Mudgal is an Associate Professor in the Department of Pharmacology.

    He is

    • A recognised PhD guide by MAHE
    • Teaching Pharmacology to postgraduate and undergraduate students
    • Guiding MPharm students in their dissertation work
    • Mentoring Postgraduate students for writing projects and applying for grants.


Subject Semester / Year
Pharmacology-2 IV BPharm
Pharmacology-III IIIBPharm
Pharmacological and Toxicological Screening methods-I First semester MPharm
Advanced Pharmacology-II Second semester MPharm


Degree Specialisation Institute Year of passing
PhD Pharmaceutical Sciences Manipal College of Pharmaceutical Sciences, Manipal University 2013


Institution / Organisation Designation Role Tenure
Department of Pharmacology, MCOPS Associate Professor Teaching and Research 2016 till date
Department of Pharmacology, MCOPS Assistant Professor Teaching and Research 2013-16
Department of Pharmacology, MCOPS Lecturer Teaching and Research 2008-13
Piramal Life Sciences Ltd (Previously known as Nicholas Piramal Research Centre), Mumbai, India Research Associate Planning, designing and execution of project work in different therapeutic areas such as inflammation, pain, diabetes, obesity and epilepsy 2007-2008


Area of Interest

Teaching Human Anatomy & Physiology, Pharmacology and pursuing research in the field of health sciences

Area of Expertise

As an academician: Teaching Pharmacology, Human Anatomy & Physiology. As a researcher: Animal model development for translational research, Standardisation of analytical techniques, Pharmacokinetic studies in biological samples, Assay development and standardisation

Area of Research

Pharmacology, Toxicology, Cellular and molecular biology, Preclinical drug discovery in the field of therapeutic areas such inflammation, pain, metabolic, neurological and oncological disorders

Professional Affiliations & Contributions

  • Life member of Association of Pharmaceutical Teachers of India.
  • Life member of Indian Pharmacology Society.
  • Life member of Association of Community Pharmacists of India.

Work Experience

Organisation Role Tenure
Piramal Life Sciences Ltd (Previously known as Nicholas Piramal Research Centre), Mumbai, India Designation: Research Associate Role: • Planning, designing and execution of project work in different therapeutic areas such as inflammation, pain, diabetes, obesity, epilepsy etc. • Documentation of work and writing research papers • Making monthly and annual progress reports and their timely submission / presentation

Total number of publications: 41

Few important research papers are listed below. For more papers, kindly browse the following link- https://manipal.pure.elsevier.com/en/persons/jayesh-mudgal

Impact of caffeic acid on aluminium chloride-induced dementia in rats

2013-01-01 Madhavan Nampoothiri G K Nandakumar Rekha Raghuveer Shenoy

2013, Journal of Pharmacy and Pharmacology, Royal Pharmaceutical Society of Great Britain, Royal Pharmaceutical Society of Great Britain, 65, 1745-1752.

Sesamol treatment reduces plasma cholesterol and triacylglycerol levels in mouse models of acute and chronic hyperlipidemia

2013-01-01 Vipin K Parihar PG Nayak Gopalan Kutty Nampurath

2013, Lipids, SpringerLink, NY, USA.

High carbohydrate diet with 30% sucrose solution: an optimised rodent model for simulating human insulin resistance

2013-01-01 AS Theerthahalli RR Shenoy PG Nayak N Kumar

2013, Pharmacologia, 4, 157-163.

Antidiabetic, antihyperlipidemic and antioxidant effects of the flavonoid rich fraction of Pilea microphylla (L) in high fat diet/streptozotocin-induced diabetes in mice

2012-01-01 P Bansal P Paul MK Unnikrishnan KI Priyadarsini

2012, Expermental and Toxicologic Pathology, Elsevier, 64, 651-658.

NO-NSAIDs. Part 3: nitric oxide-releasing pro-drugs of non-steroidal anti-inflammatory drugs

2012-01-01 Namdev Borhade Manoj Karwa Mini Dhiman Machhindra Gund

2012, Chemical and Pharmaceutical Bulletin, J-STAGE, Japan, 60, 465–481.

Ameliorative effect of caffeic acid against inflammatory pain in rodents

2011-01-01 A Mehrotra R Shanbhag MR Chamallamudi (Professor) VP Singh

2011, European Journal of Pharmacology, Elsevier, 666, 80-86.

Antioxidant, anti-inflammatory and anti-hyperglycaemic activities of heterocyclic homoprostanoid derivatives

2011-01-01 SA Manohara Reddy P Bansal SG Vasanthraju KK Srinivasan (Professor)

2011, Bioorganic and Medicinal Chemistry, Elsevier, 19, 384-392.

Anti-inflammatory activity of terminalia paniculata bark extract against acute and chronic inflammation in rats

2011-01-01 S Talwar PG Nayak P Bansal K Nandakumar

2011, Journal of Ethnopharmacology, Elsevier, 134, 323-328.

Anti-tubercular activity of synthesized novel 2,5-disubstituted-1,3,4-oxadiazole derivatives

Ega Durgashivaprasad Zenab Attari Jayesh Mudgal Bairy L Vishnuprasad S Gopalan Kutty Nampurath

Indian Drugs 2015; 52:40-44

Sesamol, a lipid lowering agent, ameliorates aluminium chloride induced behavioral and biochemical alterations in rats

Jessy John Madhavan Nampoothiri Nitesh Kumar Jayesh Mudgal Gopalan Kutty Nampurath Mallikarjuna Rao Chamallamudi

Pharmacogn Mag. 2015;11:327-36

Modulatory Role of Simvastatin against Aluminium Chloride-Induced Behavioural and Biochemical Changes in Rats

Madhavan Nampoothiri Jessy John Nitesh Kumar Jayesh Mudgal Gopalan Kutty Nampurath Mallikarjuna Rao Chamallamudi

Behav Neurol. 2015, doi: 10.1155/2015/210169

Novel 2,5-disubstituted-1,3,4-oxadiazoles as anti-inflammatory drugs

Ega Durgashivaprasad Geetha Mathew Sarine Sebastian Manohar Reddy S.A Jayesh Mudgal Gopalan Kutty Nampurath

Ind J Pharmacol. VOL. 46 | Issue 5 | September-October 2014, 521-26

Synthesis, characterization, and preclinical evaluation of new thiazolidin-4-ones substituted with p-chlorophenoxy acetic acid and clofibric acid against insulin resistance and metabolic disorder

Vasantharaju S. Gowda Jayesh Mudgal Punit Bansal Pawan G. Nayak Seethappa A Manohara Reddy Gautham G. Shenoy Manna Valiathan Mallikarjuna R. Chamallamudi Gopalan K. Nampurath

Biomed Res Int. 2014, doi: 10.1155/2014/620434

Remedial effects of novel 2,3-disubstituted thiazolidin-4-ones in chemical mediated inflammation

Jayesh Mudgal Vasantharaju S Gowda Geetha Mathew Pawan G. Nayak Nitin D. Reddy Neelesh Namdeo Ravilla R. Kumar Chaitanya Kantamaneni Mallikarjuna R. Chamallamudi Gopalan K. Nampurath

Chemico-biological interactions, 210 (2014) 34-42

Preclinical efficacy of a gastro-sparing novel thiazolidin-4-one in alleviating secondary lesions of polyarthritis: A multi-parametric approach

Jayesh Mudgal Vasantharaju S. Gowdra Piya P. Mudgal Pawan G. Nayak Nitesh Kumar Zenab Attari, C

Eur. J. Pharm. Sci., 91 (2016) 74-83. (Impact factor: 3.77 as per JCR 2015)

Dose-related antihyperglycemic and hypolipidemic effects of two novel thiazolidin-4-ones in a rodent model of metabolic syndrome.

Karot, S.S Surenahalli, V.G Kishore, A Mudgal, J Nandakumar, K Chirayil, M.T Mathew, G Nampurath, G. K

Journal of Diabetes (2016), In Press (Impact factor: 2.55, JCR 2015)

Endothelium dependent and independent mechanisms of vasorelaxant activity of synthesized 2,5-disubstituted-1,3,4-oxadiazole derivatives in rat thoracic aorta-ex vivo and molecular docking studies

Attari, Z Mudgal, J. Nayak, P.G Krishnadas, N Rajappan, R Gopalan Kutty, N

Letters in Drug Design and Discovery., 13 (2016) 441-450. (Impact factor: 0.77)

In vivo Evaluation of Two Thiazolidin-4-one Derivatives in High Sucrose Diet Fed Pre-diabetic Mice and Their Modulatory Effect on AMPK, Akt and p38 MAP Kinase in L6 Cells

Mudgal J Shetty P Kumar N Kishore A Kutty NG Nandakumar K Shenoy RR Nayak PG Rao CM Joseph A et al

Front Pharmacol. 2016 Oct 14;7:381

Extraction, characterization and evaluation of Kaempferia galanga L. (Zingiberaceae) rhizome extracts against acute and chronic inflammation in rats

Jagadish PC Latha KP Mudgal J Nampurath GK

J Ethnopharmacol. 2016 Oct 5. pii: S0378-8741(16)31155-2. doi: 10.1016/j.jep.2016.10.010. [Epub ahead of print]

Caffeic acid attenuates lipopolysaccharide-induced sickness behaviour and neuroinflammation in mice

Basu Mallik S Mudgal J Nampoothiri M Hall S Dukie SA Grant G Rao CM Arora D

Neurosci Lett. 2016 Oct 6;632:218-23. doi: 10.1016/j.neulet.2016.08.044

Neprilysin, the kidney brush border neutral proteinase: a possible potential target for ischemic renal injury

R Sankhe M Kinra J Mudgal D Arora M Nampoothiri

Toxicology mechanisms and methods 30 (2), 88-99, 2020


Effect of coffee constituents, caffeine and caffeic acid on anxiety and lipopolysaccharide-induced sickness behavior in mice

J Mudgal SB Mallik M Nampoothiri M Kinra S Hall GD Grant

Journal of Functional Foods 64, 103638, 2020


Possible involvement of metformin in downregulation of neuroinflammation and associated behavioural changes in mice

J Mudgal M Nampoothiri SB Mallik M Kinra S Hall G Grant

Inflammopharmacology 27 (5), 941-948, 2019


Improved in vitro and in vivo hepatoprotective effects of liposomal silymarin in alcohol-induced hepatotoxicity in Wistar rats

N Kumar A Rai ND Reddy RR Shenoy J Mudgal P Bansal PP Mudgal

Pharmacological Reports 71 (4), 703-712, 2019



Neuromodulatory potential of phenylpropanoids; para-methoxycinnamic acid and ethyl-p-methoxycinnamate on aluminum-induced memory deficit in rats

S Rijal N Changdar M Kinra A Kumar M Nampoothiri D Arora JMudgal

Toxicology mechanisms and methods 29 (5), 334-343, 2019


Cannabinoid receptor 2 activation mitigates lipopolysaccharide-induced neuroinflammation and sickness behavior in mice

P Sahu J Mudgal D Arora M Kinra SB Mallik CM Rao KSR Pai

Psychopharmacology 236 (6), 1829-1838, 2019

Exploring the potential of Desmodium gangeticum (L.) DC. extract against spatial memory deficit in rats

N Changdar RK Ganjhu S Rijal A Kumar SB Mallik M Nampoothiri

Pharmacognosy Magazine 15 (62), 78, 2019

Immunomodulatory role of chitosan‐based nanoparticles and oligosaccharides in cyclophosphamide‐treated mice

J Mudgal PP Mudgal M Kinra R Raval

Scandinavian journal of immunology 89 (4), e12749, 2019

InCl3 mediated heteroarylation of indoles and their derivatization via CeH activation strategy: Discovery of 2-(1H-indol-3 yl)-quinoxaline derivatives as a new class of PDE4B

B Thirupataiah J Mudgal JE Mathew GG Shenoy

European Journal of Medicinal Chemistry 174, 198-125, 2019

Effect of Caffeic Acid on Ischemia-Reperfusion-Induced Acute Renal Failure in Rats

M Kinra D Arora J Mudgal KSR Pai CM Rao M Nampoothiri

Pharmacology 103 (5-6), 315-319, 2019

Dietary oils ameliorate aluminum chloride-induced memory deficit in wistar rats

A Kumar SB Mallik S Rijal N Changdar J Mudgal RR Shenoy

Pharmacognosy Magazine 15 (60), 36, 2019

Evaluation of anticancer activity of hydroxycinnamic acid derivatives against lung cancer

Rashmi Pardeshi (PG)

The project work is focused on identifying the potential of hydroxycinnamic acid derivatives against lung cancer.

Dose dependent study of caffeic acid against inflammation and pain

2013-01-01 Ravilla Ravi Kumar (PG)

The project was aimed at the exploration of possible dose-dependent effect of caffeic acid on chronic inflammatory disorder. The project revealed the molecular mechanism of caffeic acid in amelioration of arthritis.

Evaluation of antioxidant, anticancer, anti- angiogenic and anti-inflammatory activities of the leaves of Manihot esculenta Crantz

2012-01-01 Magith Thambi (PG)

The project evaluated the aqueous and alcoholic extracts of Manihot esculenta Crantz (Euphorbiaceae) for antioxidant, anticancer, anti-angiogenic and anti-inflammatory activities using various in vitro models.

Neuro-inflammation in Alzheimer’s disease and role of caffeic acid and its derivative against aluminium chloride-induced dementia in rats

2011-01-01 Kafeel A Khan (PG)

The project described the effect of caffeic acid and p-coumaric acid against aluminium chloride-induced dementia in rats. Further, role of leukotriene receptor antagonist was studied in dementia.

A study to investigate a hypothesis that the PLGA-Nanoparticulate-Diclofenac delivers high amounts of diclofenac to the inflammatory sites

Ameena Naaz [PG]

The project was designed to develop a formulation of diclofenac sodium to target the local inflammatory site for minimising the side effects associated with chronic systemic exposure of diclofenac [2014-2015]

Modulatory role of GPR109a agonist against chemical-induced neurodegeneration in rodents

Shruti Khurana [2015-16]

Developing a patient centric health-care paradigm for oncology

2016 Amritha Remakanth

Preclinical investigation of plant extracts against dementia

2017 Nilanjan Changdar

Evaluation of phytoconstituents against preclinical models of Depression

2018 Swastika Maity

Evaluation of chemobrain and neuroinflammation in preclinical models

2019 Ankit Das