Dr D Anandh

Associate Professor

School of Regenerative Medicine

CURRENT ACADEMIC ROLE & RESPONSIBILITIES

    Dr D Anandh is Associate Professor in Manipal Institute of Regenerative Medicine

    He is :

    • Teaching courses for MSc Regenerative Medicine and Ad. Diploma in Regenerative Medicine
    • Head of Neurorestoration and Cognition Lab
    • Guide for Ph.D. Scholars
    • Setting question papers for MSc and Diploma students.
    • Internal Examiner for MSc Regenerative Medicine and Ad. Diploma in Regenerative Medicine
    • In-charge of conducting scientific talks
    • Students Admission/ Counseling
    • Generate Extra mural funding for research activities
    • Research Collaboration with National Institutes

     

 

SUBJECTS CURRENTLY TEACHING

Subject Subject code Semester
Hematopoietic stem cell Adult Stem Cell Biology Second Semester
Hematopoiesis Developmental Biology II Second Semester
Neurodegenerative Diseases: Multiple Sclerosis Stem Cells And Diseases Third Semester
Stem Cell and Restoration of Vision Applications Of Stem Cells Third Semester
Homing of Stem Cell Applications Of Stem Cells Third Semester
Tissue Engineering Applications Of Stem Cells Third Semester
BIOMOLECULES Secretory Proteins First Semester
BIOMOLECULES Proteins as hormones First Semester
BIOMOLECULES Proteins as Neurotransmitters First Semester
LABORATORY METHODOLOGIES Electrophoresis First Semester
LABORATORY METHODOLOGIES Chromatography First Semester
LABORATORY METHODOLOGIES Embedding and Sectioning and Staining First Semester
LABORATORY METHODOLOGIES Animal Models First Semester
EMBRYONIC DEVELOPMENT Neural stem cells Second Semester
ARCHITECTURE OF CELLS, TISSUE AND ORGANS Nervous System (CNS, PNS, structure of Neurons & Glia, Action potential, neural transmission) Second Semester

ACADEMIC QUALIFICATIONS

Degree Specialisation Institute Year of passing
PhD Neurophysiology National Institute of Mental Health and Neurosciences.(Deemed University, Bangalore, Karnataka. 2005
MPhil Neurophysiology National Institute of Mental Health and Neurosciences.(Deemed University, Bangalore, Karnataka 2001
MSc Biochemistry Bharathidasan University 1999
BSc Biochemistry Bharathidasan University 1997

Experience

Institution / Organisation Designation Role Tenure
Manipal Institute of Regenerative Medicine, Manipal Associate Professor 2012 - till Present

AREAS OF INTEREST, EXPERTISE AND RESEARCH

Area of Interest

Neurodegenerative Diseases, Temporal Lobe Epilepsy, Parkinson’s Disease, Stem Cell therapies, Cognition.

Area of Expertise

Stem cell therapies for Temporal Lobe Epilepsy, Parkinson’s Disease & Alzheimer’s disease.

Area of Research

Neurodegenerative diseases are devastating diseases wherein there is no identifiable treatment available so far. The primary focus of our research group is to understand the molecular, biochemical and cytoarchitectural changes that lead to progressive neurodegeneration and behavioural impairments in temporal lobe epilepsy, Parkinson’s disease and Alzheimer’s disease. From neuroprotection perspectives, we are actively exploring the possibilities of stimulating endogenous stem cells for functional recovery by means of environment manipulation, novel drug treatments and stem cell therapy. In line with this, we have demonstrated that a single intramuscular injection of genetically modified erythropoietin can protect dopaminergic neurons in animal models of Parkinson’s disease. We have also reported that transplanting hippocampal cells in brain injured rats can prevent neurodegeneration and improves cognitive functions. Currently, we are involved in understanding the molecular mechanisms of neuroprotection conferred by transplanted cells in protecting hippocampal neurons and ameliorating cognitive co-morbidities that are commonly observed in temporal lobe epilepsy, Parkinson’s disease and Alzheimer’s disease.

Professional Affiliations & Contributions

  • Research Associate, University of Tennessee Health Science Center, USA
  • Post Doctoral Fellowship, Duke University, USA
  • Post Doctroal Fellowship, Otto-von-Guerick University, Germany
  • Summer Fellow, RIKIN Brain Science Institute, Japan
  • National Institute of Mental Health and Neurosciences Fellowship, 1999-2004
  • Gold Medal, M.Phil. Neurophysiology, NIMHANS, Bangalore, 1999-2001
  • Winner of R.N.Murthy award, NIMHANS, Bangalore
  • Best Poster Award for Poster Presentation Golden APPICON 2004

 

Cytotherapy

2014-01-07 Scientific R R Bhonde Chaitra Venugopal B K Pradeep Kumar T N Sathyaprabha

Infusion of Human Embryonic Kidney Cell Line Conditioned Medium Reverses Kainic Acid Induced Hippocampal Damage in Mice

Journal of Clinical and Biomedical Sciences

2014-01-06 Scientific Chaitra Venugopal Shashank Chandanala Harishchandra Prasad YS

Stem Cells Based Therapy For Temporal Lobe Epilepsy.

Genes,Brain and Behavior

2014-01-06 Scientific Flanigan TJ Xue Y Kishan Rao Michael P McDonald

Abnormal vibrissa-related behavior and loss of barrel field inhibitory neurons in 5xFAD transgenics.

Genes, Brain and Behavior

2013-12-03 Scientific

A single intramuscular injection of rAAV-mediated mutant erythropoietin protects against MPTP-induced parkinsonism, Mar;12(2):224-33.

PLoS One

2011-01-01 Scientific Michael P McDonald

Intracranial V. cholerae sialidase protects against kainate-induced neurodegeneration, 6(12):e29285.

Neuroscience and Biobehavioral Review

2008-01-01 Scientific Shetty AK

Is Exposure to Enriched Environment Beneficial for Functional Post-Lesional Recovery in Temporal Lobe Epilepsy? , 32(4):657-74.

Behavioral Neuroscience

2009-01-01 Scientific Rehka J Sridhara C Venna LR Kalai Vani P

Transplantation of Hippocampal cell lines improves spatial learning in rats with ventral subicular lesion, 123(6):1197-217.

Behavioral Neuroscience

2007-01-01 Scientific Bindu B Raju TR Kutty BM

Exposure to Enriched Environment Improves Spatial Learning Performances and Enhances Cell Density But Not Choline Acetyltransferase Activity in The Hippocampus Of Ventral Subicular- Lesioned Rats, 121(3):491-500.

Brain Reseach Bulletin

2003-15-02 Scientific Sreekumaran E Ramakrishna T Madhav TR Sulekha S

Loss of Dendritic Connectivity in CA1, CA2 And CA3 Neurons in Hippocampus in Rat Under Aluminum Toxicity: Antidotal Effect of Pyridoxine, Feb 15;59(6):421-7.

Biomed Pharmacother

2017-27-09 Scientific Sanap A Chandravanshi B Shah T Tillu G D Anandh Bhonde R Joshi K Dhanushkodi A

Herbal pre-conditioning induces proliferation and delays senescence in Wharton's Jelly Mesenchymal Stem Cells. . 2017 Sep;93:772-778.

Neural Regen Res

2015-10-12 Scientific Shamir C Venugopal C D Anandh Dhanushkodi A

Dental pulp stem cells for treating neurodegenerative diseases. Neural Regen Res. 2015 Dec;10(12):1910-1.

Rev Diabet Stud.

2014-27-06 Scientific Chandravanshi B Dhanushkodi A D Anandh Bhonde R

High Recovery of Functional Islets Stored at Low and Ultralow Temperatures. Rev Diabet Stud. 2014 Fall-Winter;11(3-4):267-78.

J Tissue Eng Regen Med.

2017-11-02 Scientific Venugopal C Chandanala S Prasad HC Nayeem D D Anandh Dhanushkodi A Bhonde R

Regenerative therapy for hippocampal degenerative diseases: lessons from preclinical studies. J Tissue Eng Regen Med. 2017 Feb;11(2):321-333.

J Toxicol.

2014-27-09 Scientific Bevinahal PK Venugopal C Yencharla HC Chandanala S D Anandh Talakad SN Bhonde RR Dhanushkodi A Trichur RR

Conditioned Medium Reconditions Hippocampal Neurons against Kainic Acid Induced Excitotoxicity: An In Vitro Study. 194967.

Neurotoxicology

2017-06-12 Scientific Prasad YSHC Venugopal C Dhanushkodi A Pinnelli VB Shobha K

HEK-293 secretome attenuates kainic acid neurotoxicity through insulin like growth factor-phosphatidylinositol-3-kinases pathway and by temporal regulation of antioxidant defense machineries.

Curr Gene Ther

2018-24-01 Scientific Shamir C Venugopal C Dhanushkodi A Shobha K Rai KS Nishtha KJ Sonu PK Babu JV Senthilkumar S

Dosage and Passage Dependent Neuroprotective Effects of Exosomes Derived from Rat Bone Marrow Mesenchymal Stem Cells: An In Vitro Analysis.

HEK cell line derived secretome foster neuroprotection via suppressing oxidative stress and augmenting neurogenesis in an in vitro model of neurodegeneration

2014-01-01 Harish Chandra Prasad YS (MSc)

Neuroprotective ability of conditioned medium derived from human embryonic kidney cells against Kainic acid induced neurodegeneration: In vitro condition

2013-01-01 B.K. Pradeep Kumar (MSc)

Human embryonic kidney cells and its conditioned medium protects hippocampal neurodegeneration induced by Kainic acid in vivo condition

2013-01-01 Chaitra Venugopal (MSc)