CURRENT ACADEMIC ROLE & RESPONSIBILITIES
- Teaching courses for MSc Regenerative Medicine and Ad. Diploma in Regenerative Medicine
- Head of Neurorestoration and Cognition Lab
- Guide for Ph.D. Scholars
- Setting question papers for MSc and Diploma students.
- Internal Examiner for MSc Regenerative Medicine and Ad. Diploma in Regenerative Medicine
- In-charge of conducting scientific talks
- Students Admission/ Counseling
- Generate Extra mural funding for research activities
- Research Collaboration with National Institutes
Dr D Anandh is Associate Professor in Manipal Institute of Regenerative Medicine
He is :
SUBJECTS CURRENTLY TEACHING
|Hematopoietic stem cell||Adult Stem Cell Biology||Second Semester|
|Hematopoiesis||Developmental Biology II||Second Semester|
|Neurodegenerative Diseases: Multiple Sclerosis||Stem Cells And Diseases||Third Semester|
|Stem Cell and Restoration of Vision||Applications Of Stem Cells||Third Semester|
|Homing of Stem Cell||Applications Of Stem Cells||Third Semester|
|Tissue Engineering||Applications Of Stem Cells||Third Semester|
|BIOMOLECULES||Secretory Proteins||First Semester|
|BIOMOLECULES||Proteins as hormones||First Semester|
|BIOMOLECULES||Proteins as Neurotransmitters||First Semester|
|LABORATORY METHODOLOGIES||Electrophoresis||First Semester|
|LABORATORY METHODOLOGIES||Chromatography||First Semester|
|LABORATORY METHODOLOGIES||Embedding and Sectioning and Staining||First Semester|
|LABORATORY METHODOLOGIES||Animal Models||First Semester|
|EMBRYONIC DEVELOPMENT||Neural stem cells||Second Semester|
|ARCHITECTURE OF CELLS, TISSUE AND ORGANS||Nervous System (CNS, PNS, structure of Neurons & Glia, Action potential, neural transmission)||Second Semester|
|Degree||Specialisation||Institute||Year of passing|
|PhD||Neurophysiology||National Institute of Mental Health and Neurosciences.(Deemed University, Bangalore, Karnataka.||2005|
|MPhil||Neurophysiology||National Institute of Mental Health and Neurosciences.(Deemed University, Bangalore, Karnataka||2001|
|Institution / Organisation||Designation||Role||Tenure|
|Manipal Institute of Regenerative Medicine, Manipal||Associate Professor||2012 - till Present|
AREAS OF INTEREST, EXPERTISE AND RESEARCH
Area of Interest
Neurodegenerative Diseases, Temporal Lobe Epilepsy, Parkinson’s Disease, Stem Cell therapies, Cognition.
Area of Expertise
Stem cell therapies for Temporal Lobe Epilepsy, Parkinson’s Disease & Alzheimer’s disease.
Area of Research
Neurodegenerative diseases are devastating diseases wherein there is no identifiable treatment available so far. The primary focus of our research group is to understand the molecular, biochemical and cytoarchitectural changes that lead to progressive neurodegeneration and behavioural impairments in temporal lobe epilepsy, Parkinson’s disease and Alzheimer’s disease. From neuroprotection perspectives, we are actively exploring the possibilities of stimulating endogenous stem cells for functional recovery by means of environment manipulation, novel drug treatments and stem cell therapy. In line with this, we have demonstrated that a single intramuscular injection of genetically modified erythropoietin can protect dopaminergic neurons in animal models of Parkinson’s disease. We have also reported that transplanting hippocampal cells in brain injured rats can prevent neurodegeneration and improves cognitive functions. Currently, we are involved in understanding the molecular mechanisms of neuroprotection conferred by transplanted cells in protecting hippocampal neurons and ameliorating cognitive co-morbidities that are commonly observed in temporal lobe epilepsy, Parkinson’s disease and Alzheimer’s disease.
Professional Affiliations & Contributions
- Research Associate, University of Tennessee Health Science Center, USA
- Post Doctoral Fellowship, Duke University, USA
- Post Doctroal Fellowship, Otto-von-Guerick University, Germany
- Summer Fellow, RIKIN Brain Science Institute, Japan
- National Institute of Mental Health and Neurosciences Fellowship, 1999-2004
- Gold Medal, M.Phil. Neurophysiology, NIMHANS, Bangalore, 1999-2001
- Winner of R.N.Murthy award, NIMHANS, Bangalore
- Best Poster Award for Poster Presentation Golden APPICON 2004
2014-01-07 Scientific R R Bhonde Chaitra Venugopal B K Pradeep Kumar T N Sathyaprabha
Infusion of Human Embryonic Kidney Cell Line Conditioned Medium Reverses Kainic Acid Induced Hippocampal Damage in Mice
Journal of Clinical and Biomedical Sciences
2014-01-06 Scientific Chaitra Venugopal Shashank Chandanala Harishchandra Prasad YS
Stem Cells Based Therapy For Temporal Lobe Epilepsy.
Genes,Brain and Behavior
2014-01-06 Scientific Flanigan TJ Xue Y Kishan Rao Michael P McDonald
Abnormal vibrissa-related behavior and loss of barrel field inhibitory neurons in 5xFAD transgenics.
Genes, Brain and Behavior
A single intramuscular injection of rAAV-mediated mutant erythropoietin protects against MPTP-induced parkinsonism, Mar;12(2):224-33.
2011-01-01 Scientific Michael P McDonald
Intracranial V. cholerae sialidase protects against kainate-induced neurodegeneration, 6(12):e29285.
Neuroscience and Biobehavioral Review
2008-01-01 Scientific Shetty AK
Is Exposure to Enriched Environment Beneficial for Functional Post-Lesional Recovery in Temporal Lobe Epilepsy? , 32(4):657-74.
2009-01-01 Scientific Rehka J Sridhara C Venna LR Kalai Vani P
Transplantation of Hippocampal cell lines improves spatial learning in rats with ventral subicular lesion, 123(6):1197-217.
Exposure to Enriched Environment Improves Spatial Learning Performances and Enhances Cell Density But Not Choline Acetyltransferase Activity in The Hippocampus Of Ventral Subicular- Lesioned Rats, 121(3):491-500.
Brain Reseach Bulletin
2003-15-02 Scientific Sreekumaran E Ramakrishna T Madhav TR Sulekha S
Loss of Dendritic Connectivity in CA1, CA2 And CA3 Neurons in Hippocampus in Rat Under Aluminum Toxicity: Antidotal Effect of Pyridoxine, Feb 15;59(6):421-7.
2017-27-09 Scientific Sanap A Chandravanshi B Shah T Tillu G D Anandh Bhonde R Joshi K Dhanushkodi A
Herbal pre-conditioning induces proliferation and delays senescence in Wharton's Jelly Mesenchymal Stem Cells. . 2017 Sep;93:772-778.
Neural Regen Res
2015-10-12 Scientific Shamir C Venugopal C D Anandh Dhanushkodi A
Dental pulp stem cells for treating neurodegenerative diseases. Neural Regen Res. 2015 Dec;10(12):1910-1.
Rev Diabet Stud.
2014-27-06 Scientific Chandravanshi B Dhanushkodi A D Anandh Bhonde R
High Recovery of Functional Islets Stored at Low and Ultralow Temperatures. Rev Diabet Stud. 2014 Fall-Winter;11(3-4):267-78.
J Tissue Eng Regen Med.
2017-11-02 Scientific Venugopal C Chandanala S Prasad HC Nayeem D D Anandh Dhanushkodi A Bhonde R
Regenerative therapy for hippocampal degenerative diseases: lessons from preclinical studies. J Tissue Eng Regen Med. 2017 Feb;11(2):321-333.
2014-27-09 Scientific Bevinahal PK Venugopal C Yencharla HC Chandanala S D Anandh Talakad SN Bhonde RR Dhanushkodi A Trichur RR
Conditioned Medium Reconditions Hippocampal Neurons against Kainic Acid Induced Excitotoxicity: An In Vitro Study. 194967.
2017-06-12 Scientific Prasad YSHC Venugopal C Dhanushkodi A Pinnelli VB Shobha K
HEK-293 secretome attenuates kainic acid neurotoxicity through insulin like growth factor-phosphatidylinositol-3-kinases pathway and by temporal regulation of antioxidant defense machineries.
Curr Gene Ther
2018-24-01 Scientific Shamir C Venugopal C Dhanushkodi A Shobha K Rai KS Nishtha KJ Sonu PK Babu JV Senthilkumar S
Dosage and Passage Dependent Neuroprotective Effects of Exosomes Derived from Rat Bone Marrow Mesenchymal Stem Cells: An In Vitro Analysis.