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Overview

  • Department of Pharmacology in Manipal College of Pharmaceutical Sciences was established in 1965 and has been catering to the needs of undergraduate and postgraduate students. It is offering the masters program (MPharm) in Pharmacology since 1970. Currently, there are 9 faculty, 30 Postgraduate students and over 20 research scholars in the Department.
  • Eminent medical pharmacologists- Dr. V K Bopardikar, Dr. M N Guruswami and Dr. Druva Ranganath Kulkarni were the first three heads of the department. After they retired, the baton passed on to younger teachers – Dr. Ahalya Devi, Dr. Sudhakara Karanth and Dr. K Laxminarayana Bairy. Teachers with MPharm and MSc qualifications were also staff in the department. It was left to them to handle diploma and BPharm programs. The senior teachers supervised MPharm and PhD.  MPharm in pharmacology started in 1971 and Mr. Kiran Shankar (Vice President, Marketing, Wintac, Bangalore) was the first student who secured MPharm in Pharmacology.
  • Manipal College of Pharmaceutical Sciences got its full-fledged, independent Pharmacology department on 1 November 2001 by transferring faculty hitherto associated with pharmacy programs from KMC Pharmacology Department.  Dr. Ravindranath Shanbhag was the first to head the new department. The present principal of MCOPS, Dr. C Mallikarjuna Rao, succeeded Dr. Shanbhag and was at the helm for 10 years. From 2014 onwards, Dr. K Sreedhara R Pai has been the head of the department.
  • The department has grown in men and materials- faculty and infrastructure since it moved to MCOPS.
  • Now housed in a spacious four-storeyed building, the department has three big laboratories, a cell culture lab, library, air-conditioned seminar and instrument rooms, faculty rooms and office room. The three big labs, named after former illustrious professors, Bopardikar, Guruswami, and Kulkarni, are used for BPharm, MPharm I practical and MPharm II research. Besides facilities for isolated tissue and simple in vivo experiments, these labs have premier instruments for several drug evaluation procedures.  Just to name a few: Ugo Basile plethysmometer, analgesiometer, Hargreaves apparatus, Power Lab and so on.
  • The instrument room has some of the sophisticated, state-of-the-art instruments, mainly acquired through grants secured from funding agencies by faculty. The flow cytometer, HPLC, fluorescent microscope, inverted microscope, UV spectrophotometer, ELISA plate reader, gel documentation system, Trans-Blot (for Western Blot) and CO2 incubator are some of the notable instruments that support high-quality research work.
  • BPharm students have Pharmacology in their 4th, 5th, 6th and 8th semesters in their four-year program comprising 8 semesters. For PharmD, pharmacology is taught in the second and third years and for DPharm in the second year. Also, the Department handles Human Anatomy and Physiology for first-year (1 & 2 semesters) BPharm, PharmD and DPharm students.

 

Program

MPharm Pharmacology

This is a two-year program comprising four semesters designed to provide advanced training in various aspects of pharmacology, molecular biology, pre-clinical & clinical drug development and pharmacotherapeutics. There are excellent experiments to be carried out in each of these areas, which equip the student with skills for research. The program has tremendous scope and students who emerge successfully have various career options. They are a much sought-after tribe in academia and industry. They can enter the teaching profession, find employment in pharmaceutical companies in R&D, clinical research organizations, medical writing as well as in research.

The department has succeeded in finding suitable employment for those who have completed MPharm. Many of our alumni are very well placed, either in India or abroad.

The annual intake of MPharm pharmacology branch is fifteen students.

 

Why Pharmacology as a career option?

Pharmacology is a subject, which connects the other disciplines of pharmaceutical sciences with medicine. This branch of science equips a student with the ability to appreciate the establishment of dose, dosage, efficacy, and safety of medicines, their mechanisms, and disposition. Pharmacology gives immense scope for exploration into diversified subdomains such as signaling and molecular mechanisms of medicines, clinical pharmacology and biopharmaceutics, non-clinical and clinical trials. This opens up opportunities for further academic upgradation, sometimes with funded research projects of national importance supported by government funding agencies.

The pharmaceutical industry, especially clinical research organizations offers a variety of career opportunities in different business verticals such as basic pharmacological research, pre-clinical toxicology, clinical pharmacology, quality assurance and compliance, medical/scientific writing, pharmacovigilance, marketing (scientific/product management) and many more…

Course Training for MPharm

The department imparts training in the following subjects which facilitates the students to build their theoretical and practical knowledge

Semester I [part-1]

  • PQA-MPL101T: Modern Pharmaceutical Analytical Techniques
  • PHA-MPL102T: Advanced Pharmacology-I
  • PHA-MPL103T: Pharmacological and Toxicological Screening Methods-I
  • PHA-MPL104T: Cellular and Molecular Pharmacology
  • PHA-MPL105P: Pharmacology Practical I
  • PHA-MPL106S: Seminar

Semester II [part-1]

  • PHA-MPL201T: Advanced Pharmacology- II
  • PHA-MPL202T: Pharmacological and Toxicological Screening Methods- II
  • PHA-MPL203T: Principles of Drug Discovery
  • PHA-MPL204T: Clinical Research and Pharmacovigilance
  • PHA-MPL205P: Pharmacology Practical II
  • PHA-MPL206S: Seminar

Semesters III and IV [part-2]

  • PHA-MRM301T: Research Methodology and Biostatistics
  • MJC 302P: Journal Club
  • MRW 401P: Research work**

**Research work for projects on various topics like:

  • Toxicity studies
  • Screening of new chemical entities for pharmacological activities
  • In-vitro and in-vivo experiments
  • Elucidation of cellular and molecular mechanisms
  • Drug interactions
  • Pharmacokinetic studies

Students have undergone internships during MPharm part -2 at Aurigene, Dr. Reddy’s, Novartis, etc

 

Job options

  • Research scientist in R & D
  • Clinical research associate in CRO
  • Business development [BD] in CRO
  • Pharmaceutical company [basic research]
  • Pharmacovigilance
  • Academia
  • Medical/ scientific writing

 

Further opportunities

  • MPharm students can pursue PhD, both in India and abroad
  • Junior research fellow [JRF] in Government of India funded and industrial projects

 

Core Competencies

  • Tissue-based experiments
  • Animal handling
  • In-vivo and invitro pharmacological experimentation
  • Academic pre-requisites of clinical research

Key Features

  • Finest infrastructure with sophisticated and well-equipped laboratories.
  • Hands-on training in vitro and in vivo experimental pharmacology.
  • Full-fledged cell culture lab (Western blotting, flow cytometry, cell analyzer).
  • Technical skills in instrument handling (HPLC, Electrophoresis, Fluorescent imaging,).
  • Industry sponsored projects to provide a rich experience to research scholars and MPharm students.

 

Research

The Department of Pharmacology has top-drawer facilities for research. Research in cancer, metabolic disorders, inflammatory diseases, chemoprevention, wound healing and tissue repair, neuro-pharmacology, diabetes, and psycho-pharmacology is being carried out in the department. Faculty, research scholars and postgraduate students are actively involved in research projects. A number of projects have received funding from AICTE, DBT, and DST. The department has developed tie-up with several industries to undertake work on their drugs and formulations. This is a win-win situation for the department as well as the company concerned. This also has paved the way for young MPharm degree holders to get a footing in research along with some financial assistance. Many of these candidates later get the opportunity to get into full-scale research leading to PhD. The Department of Pharmacology has thus helped many a candidate to work for the doctoral degree.

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Collaborations

  • Harvard University and Molecular Neurotherapy and Imaging Laboratory in the departments of Radiology and Neurology at Massachusetts General Hospital.
  • Griffith University, Australia
  • Enovate Bio Life, Mumbai
  • Wyoming University, USA
  • Indus Biotech, Pune
 
Placement                 
  • Syngene International
  • IQVIA
  • Indegene Life Systems
  • Biocon
  • Astra Zeneca
  • Advinus
  • Novartis
  • Dr. Reddy's
  • Decision Resources Group
Instrumentation

State of art instrumentation facility for Cellular & molecular biology, analytical and bioanalytical studies. Department is having full access of Central animal house research facility.

Industrial projects

Successfully completed more than 10 company sponsored toxicology projects and more than 30 efficacy testing projects. Recently two projects from biomedical devices testing has been completed. On an average every year department handles more than 4 industry projects.

Research Projects

Different ongoing projects in the department are in the fields of metabolic disorder, sports medicine, hepatoprotection, neuroprotection, mood disorder, cancer, inflammation, wound healing etc.

Faculty

Facilities and Services

Department of Pharmacology, MCOPS has best-in-class facilities for students of all constituent institutes

Research facilities

State-of-the-art animal house, breeding rooms and sophisticated instruments

Staff and Students

Experienced teaching and supporting staff; dedicated students and research scholars

Activities

Departmental activities (guest lectures, post-graduate lecture updates, seminars, workshops, conference)

Placement

Placement in top pharmaceutical companies-Dr Reddy's, Mylan, Advinus, Novartis, Zydus, Ranbaxy

Department Library

Libraries give students access to study resources

Services

Department offers services such as research collaborations, sample analysis

Research & Publications

The Department of Pharmacology, MCOPS is involved in research along with its academic activities. From 2001 onwards until 2019, the department has published 250 research papers in reputed national and international journals. The staff, research scholars and postgraduate students have also attended national and international conferences and made paper/poster presentations of their research work. Cancer is one area where the department has contributed significantly. Besides, active research is currently on in wound repair, inflammation, diabetes, dyslipidemias, hypertension, learning and memory, Alzheimer’s disease, Parkinsonism and behavioural studies. New targets for the treatment of these diseases are being sought through in vitro and in vivo experiments. The faculty and research scholars of the department have secured several grants to promote research. To put this in perspective, a few grants are being listed. They are All India Council of Technical Education’s (AICTE) Research Promotion Scheme (RPS), Modernization and removal of obsolescence (MODROBS) and Career Award for Young Teachers; DST Fast-track Scheme for Young Scientists, etc. The department has labs dedicated for research. Research is supported by excellent lab facilities with sophisticated instruments, most of them procured through grants from funding agencies. Consequently, the department boasts the presence of Flow Cytometer, Western Blot set up, HPLC, gel documentation, ELISA plate reader, semi-auto analyser, inverted microscope, spectrophotometers, Ugo Basile plethysmometer, analgesimeter, Power Lab and so on. A cell culture lab helps experiments using cell lines. Work on cell lines is much more ethically acceptable than work on live animals. Tie-up with industries has given rise to research projects, beneficial to both the institution and industry concerned. A few candidates are able to carry out their PhD work in collaboration with industries. Plant extracts and compounds isolated from plants have been used for research. Significant work is in progress on developing new chemical entities (NCE) as drug candidates.

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