Abstract Patients seeking dental treatment may have known or unknown underlying allergies. The manifestation of these immunological reactions may range from mild rashes to life threatening conditions such as laryngeal edema. A good understanding of the various drugs and dental materials which can cause these allergies are necessary to taking adequate precautions to prevent any untoward incidences. Apart from patients, allergic reactions to certain dental materials and substances can be also be seen in the dental health care providers. Clinical relevance: This article describes the various hypersensitivity reactions and highlight the dental considerations in managing these hypersensitivity reactions that can been seen during dental practice.