Sajan Daniel George


Department of Atomic & Molecular Physics


    Sajan Daniel George is a Professor in the Department of Atomic and Molecular Physics.

    He is:

    • Coordinator - Center for Applied Nanosciences (CAN)
    • Dr. T M A Pai Endowment Chair in Applied Nanosciences
    • Research Coordinator - Department of Atomic and Molecular Physics
    • Member – Interdisciplinary Research Advisory Group – Manipal Academy of Higher Education
    • Coordinator – Admissions, Department of Atomic and Molecular Physics
    • Coordinator – PG course in Nanoscience and Technology
    • Coordinator – Placement Cell, Department of Atomic and Molecular Physics
    • International Coordinator for Department of Atomic and Molecular Physics
    • Group Leader – DST-FIST program of the Department
    • Member – Board of Studies, Department of Atomic and Molecular Physics
    • PI- Govt. Funded Projects
    • Guide – Ph.D and M. Sc students



Subject Subject code Semester
Applied Nanotechnology MSN 703 Third
Nanomaterials – Preparation and Characterisation MSN 602 Second
Fundamentals of Advanced Optics MSN 603 First


Degree Specialisation Institute Year of passing
PhD Photonics CUSAT, Kochi 2004


Institution / Organisation Designation Role Tenure
Department of Atomic and Molecular Physics Professor 2018 to till date
Department of Atomic and Molecular Physics Associate Professor 2012 to 2018
Technical University of Darmstadt, Germany Scientist 2009 to 2012
Leibniz University of Hannover, Germany Scientist 2007 to 2009
Department of Atomic and Molecular Physics Assistant Professor 2006 to 2007
Department of Atomic and Molecular Physics Research Associate 2005 to 2006
Katholikek University of Leuven, Belgium KU Leuven Fellow 2004 to 2005


Area of Interest


Area of Expertise

Nanophotonics, Photothermal methods, Biomedical Applications of Laser, Micro/ Optofluidics, Particle trapping and tweezing.

Area of Research

Nanoparticle based bioimaging, Plasmonic control of emission, Micro and Optofluidic Technologies, Optical Tweezers, Marangonic Tweeezers, Spectrosocpic techniques for disease detection.

Professional Affiliations & Contributions

  • Editorial Board Member, Scientific Reports, Nature Publishers, USAEditorial Board Member, Materials Science and Engineering Progress, Engineers Press Group, AustriaEditorial Board Member, Soft Nanoscience  Letters, Scientific Research, USAEditorial Board Member, Asian Journal of Physical Sciences, IndiaReviewer Panel Member of Department of Defense, U S A Reviewer Panel Member of National Research Council, Government of Romania
  • Reviewer of various journals of the following publishers (for more than 30 journals since 2003) : Springer, American Institute of Physics, RCSC publishers, Taylor & Francis, Elsevier Publications, SPIE Publications, American Scientific Publishers and International Conferences
  • Invited Member – American Nano Society
  • Life Member – Photonics Society of India
  • Life Member – Indian Laser Association




Particle manipulation based on optically controlled free surface hydrodynamics

2013-01-08 SubramanyanNamboodiri Varanakkottu Tobias Baier Steffen Hardt, Markus Biesalski

2013, Ang Chem Int Edition, Wiley Publishers, Vol 52, Pg 7291 – 7295,Photoswitchable molecules that undergo reversible structural change upon light irradiation have numerous applications, ranging from life science to interfacial fluid mechanics. The objective of this article is to demonstrate that photoswitchable molecules also enable the manipulation of micron-sized particles. Commonly employed particle manipulations techniques rely on the so-called gradient force that scales as the third power of the particle diameter in the Rayleigh regime. For this reason the trapping force rapidly diminishes with decreasing particle diameter. Here we present an optical method for the trapping and manipulation of micron-sized particles adsorbed at a gas–liquid interface based on optically induced Marangoni flow. The hydrodynamic nature of the trapping mechanism implies a force scaling with the particle diameter instead of its third power. The method relies on photo responsive surfactants adsorbed to the interface that can be reversibly switched between two isomeric states. It is experimentally demonstrated that,using optically induced Marangoni flow,microspheres can be manipulated using lower light intensities compared to conventional optical tweezers.

Thermal lens probing of distance dependent fluorescence quenching of rhodamine 6G by silver nanoparticles

2013-01-01 Achmma Kurian N Shemeena Basheer B Rajesh Kumar

Journal of Luminescence, Elsevier, Vol 137, Pg 225-229.Manipulation of the characteristics of laser dyes using metal nanoparticles is one of the rapidly growing areas in nanotechnology due to their promising applications in diverse fields, ranging from biomedical imaging to green energy. The energy transfer behaviour of a silver nanoparticle (Ag NP) with a dye molecule, Rhodamine 6G (Rh 6G), is interrogated using static photoluminescence as well as a laser based dual beam thermal lens technique. Spherical Ag NPs of various concentrations are prepared using chemical reduction method and is mixed with a fixed concentration of Rh 6G. It is observed that the intrinsic fluorescence of Rh 6G (1 microMolar) is quenched in proximity of the Ag NPs and the quenching efficiency increases with an increase in Ag NP concentration (2.5*10exp(-4) – 10*10exp(-4) M). The dye–NP distance is evaluated by varying the concentrations of Ag NPs and it is found to decrease with an increase in the NP concentration in the mixture from 92 to 69 Angstroms. The distance dependent energy transfer efficiency showed that dye–NP mixture follows Rexp (-4) dependence, where R is the dye–NP distance.

Evaluation of High Performance Liquid Chromatography - Laser Induced Fluorescence (HPLC-LIF) for serum protein profiling for the early diagnosis of oral cancer

2010-01-01 VK Unnikrishnan MSc A Patel V Prabhu K Choudhari

Journal of Biomedical Optics, SPIE, 15, 067007.The present work deals with the evaluation of a high performance liquid chromatography laser-induced fluorescence (HPLCLIF) technique developed in our laboratory for early detection of oral cancer from protein profiles of body fluids. The results show that protein profiles of serum samples from a given class of samples, say, normal, premalignant, or malignant, are statistically very close to each other, while profiles of members of any class are significantly different from other classes. The performance of the technique is evaluated by the use of sensitivity and specificity pairs, receiver operating characteristic (ROC) analysis, and Youden’s Index. The technique uses protein profile differences in serum samples, registered by the HPLC-LIF technique. The study is carried out using serum samples from volunteers diagnosed as normal or premalignant clinically, and as malignant by histopathology. The specificities and sensitivities of the HPLC-LIF method at an ideal threshold (M-distance = 2) for normal, malignant, and premalignant classes are 100, 69.5, and 61.5%, and 86.5, 87.5, and 87.5%.

Thermal characterisation of doped polyaniline and its composites with CoPc

2004-01-01 P Radhakrishnan S Venketachalam MR Ananatharaman, S Saravanan

Physical Review B, 69, 235201,Thermal diffusivity of the composites of camphor sulphonic acid (CSA) doped polyaniline (PANI) and its composites with cobalt phthalocyanine (CoPc) have been measured using open cell photoacoustic technique. Analysis of the data shows that the effective thermal diffusivity value can be tuned by varying the relative volume fraction of the constituents. It is seen that polaron assisted heat transfer mechanism is dominant in CSA doped PANI and these composites exhibit a thermal diffusivity value which is intermediate to that of CSA doped PANI and CoPc. The results obtained are correlated with the electrical conductivity and hardness measurements carried out on the samples.

Photothermal deflection measurement on heat transport in GaAs epitaxial layers

2003-01-01 CPG Vallabhan. P Radhakrishnan VPN Nampoori

68,165319,This paper reported the in-plane and cross-plane measurements of the thermal diffusivity of double epitaxial layers of n-type GaAs doped with various concentrations of Si and a p-type Be-doped GaAs layer grown on a GaAs substrate by the molecular beam epitaxial method, using the laser-induced non-destructive photothermal deflection technique. The thermal diffusivity value is evaluated from the slope of the graph of the phase of the photothermal deflection signal as a function of pump-probe offset. Analysis of the data shows that the cross-plane thermal diffusivity is less than that of the in-plane thermal diffusivity. It is also seen that the doping concentration has a great influence on the thermal diffusivity value. Measurement of p-type Be-doped samples shows that the nature of the dopant also influences the effective thermal diffusivity value. The results are interpreted in terms of a phonon-assisted heat transfer mechanism and the various scattering process involved in the propagation of phonons.

Crystallisation using optical forces


PG (Co-Guided), Fourth.Structure based drug design is the process of determining the structure of a protein and designing the drug molecules that can bind and control its function. X-ray crystallographic studies provide unambiguous, accurate, and reliable three dimensional structural parameters. However, obtaining high quality protein crystals of sufficient size is always a challenging task. In order to circumvent to this difficulty, various approaches including photo chemically induced nucleation have been employed. In this work, we demonstrate the application of photothermal heating effects by laser on the growth of small molecule crystals. The present study clearly shows that laser induced heating effects can accelerate the crystal formation and aid in the formation of high quality crystals. The influence of light absorbing objects at the focal plane of laser beam on the crystallisation rate is also investigated.

A Raman Spectroscopic study of Post-Menopausal Osteoporosis


UG (Guided), Sixth.Osteoporosis is a condition that features loss of the normal density of bone and fragile bone. Osteoporosis leads to literally abnormally porous bone that is more compressible like a sponge, than dense like a brick. We induced osteoporosis in small animals (mice) and exploited the possibility of Raman spectroscopic technique combined with multivariable analysis tool (Principal Component Analysis) for the differentiation of different stages of osteoporosis.

    Particle Manipulation Based on Optically Controlled Free Surface Hydrodynamics


    (Angewandte Chemie International Edition 07/2013; 52(28):7291–7295) selected under Hot Topics of Wiley Surfaces and Interfaces section.

    Microfluidics-A Lab in Your Palm

    (Resonance, July 682-690) - cover article of the issue.

    Evaluation of High Performance Liquid Chromatography -  Laser Induced Fluorescence (HPLC-LIF) for serum protein profiling for the early diagonsis of oral cancer

    Journal of Biomedical Optics, 15, 067007 (2010) - also for Virtual Journal of Biological Physical Research, 21(1), (2011)

    Optofluidics – Marriage of light with fluids

    Biophotoics Research at Manipal

    Photonics News, a publication of International School of Photonics, CUSAT, Cochin, India (2007)

    Photothermal deflection measurement on heat transport in GaAs epitaxial layers

    Physical Review B, 68, 165319 (2003) - also for Virtual Journal of Ultrafast Sciences, 2 (11), (2003).