Chemotherapy is still one of the major treatment modality either as single treatment modality or in combination with other modalities such as surgery and /or radiotherapy. With improvement in technology, better understanding of the pathogenesis of cancer and increased awareness among the people has led to increase in long term cancer survivors. Most of the cancer survivors may wish to have their progeny in their reproductive age. However, the poor quality of gametes or total loss of gametogenesis following chemotherapy can lead to infertility. Therefore, post chemotherapy effect on quality of gametes and fertility preservation have become important issues in the area of reproductive medicine as quality and number of spermatozoa plays an important role on the reproductive outcome. Moringa Oleifera is a plant with potential medicinal properties. Various parts of the plant such as root, leaves, bark, flower and fruits have been used in the preparation of traditional Ayurvedic medicines for treating various diseases. The leaves are of high nutrition value and are rich source of -carotene, protein, vitamin C, calcium and potassium and act as a good source of natural antioxidants. Our aim is to exploit the medicinal property of this plant in protecting the gonadal tissue from chemotherapy (cyclophosphamide) induced damage. In addition understanding the mechanism of chemoprotection offered by this extract and identification and isolation of the active component of the leaf extract responsible for chemoprotection is the aim of this project. (Supported by Indian Council of Medical Research, Govt. of India)