CURRENT ACADEMIC ROLE & RESPONSIBILITIES
Role- Assistant Professor, Department of Reproductive Science
Responsibilities-
1. Involved in teaching and mentoring postgraduate students of M.Sc. Reproductive Genetics course
2. Recognized PhD guide from MAHE, Manipal
3. Involved in thesis guidance of master’s course students and Ph.D. scholars’ supervision
4. Involved in research on the genetics of infertility disorders and congenital defects, involved in applying for grants and procuring funding as principal investigator for projects
SUBJECTS CURRENTLY TEACHING
| Subject | Semester / Year |
|---|---|
| Reproductive Genetics | I, II, III |
ACADEMIC QUALIFICATIONS
| Degree | Specialisation | Institute | Year of passing |
|---|---|---|---|
| Ph. D. | Human Genetics | University of Delhi | 06/2016 |
| M.Sc. | Genetics | University of Delhi | 06/2010 |
| B.Sc. | Biochemistry Hons. | University of Delhi | 06/2008 |
Experience
| Institution / Organisation | Designation | Role | Tenure |
|---|---|---|---|
| Strand Life Sciences India Pvt. Ltd., Bangalore, Karnataka | Senior Scientist II | Research | August 2021- July 2023 |
| Dana-Farber Cancer Institute, Boston, MA, USA | Postdoctoral Research Fellow | Research | May 2019- July 2021 |
| Mayo Clinic, Rochester, MN, USA | Postdoctoral Research Fellow | Research | Sep 2016- May 2019 |
| All India Institute of Medical Sciences, New Delhi | Research Associate | Research | Nov 2015- Sep 2016 |
Name of the project: Uncovering genetic causes for familial cases of female infertility disorders
Principal investigator: Dr. Aditi Gupta
Funding agency: Intramural funding from MAHE
Overview: This project involves investigating families with multiple women affected with infertility-associated debilitating conditions such as endometriosis and subjecting them to whole exome sequencing (WES) to help identify potential monogenic causes of the disease. Endometriosis is an estrogen‑dependent severe gynecological disease characterized by chronic pain, inflammation and impaired fertility. This debilitating condition affects about 10% women of reproductive age, which accounts for ~247 million women globally and ~42 million women in India, thus a huge public burden and extremely critical to investigate its etiology to find novel diagnostics and therapeutics.
AREAS OF INTEREST, EXPERTISE AND RESEARCH
Area of Interest
Reproductive Genetics
Area of Expertise
Human Genetics, Medical Genomics
Area of Research
Rare genetic disorders, Congenital defects, infertility related disorders
Professional Affiliations & Contributions
Contributions-
Projects funded- 1
PhD students currently guiding- 1
Postgraduate M.Sc. Dissertation students guided- 2
NCBI link -https://www.ncbi.nlm.nih.gov/myncbi/aditi.gupta.8/bibliography/public/
Key Publications- 1. Lampson BL, Gupta A, Tyekucheva S, Mashima K, Petráčková A, Wang Z, Wojciechowska N, Shaughnessy CJ, Baker PO, Fernandes SM, Shupe S, Machado JH, Fardoun R, Kim AS, Brown JR. Rare Germline ATM Variants Influence the Development of Chronic Lymphocytic Leukemia. J Clin Oncol. 2023 Feb 10;41(5):1116-1128. doi: 10.1200/JCO.22.00269. Epub 2022 Oct 31. PubMed PMID: 36315919; PubMed Central PMCID: PMC9928739. 2. Gupta A, Dsouza NR, Zarate YA, Lombardo R, Hopkin R, Linehan AR, Simpson J, McCarrier J, Agre KE, Gavrilova RH, Stephens MC, Grothe RM, Monaghan KG, Xie Y, Basel D, Urrutia RA, Cole CR, Klee EW, Zimmermann MT. Genetic variants in DGAT1 cause diverse clinical presentations of malnutrition through a specific molecular mechanism. Eur J Med Genet. 2020 Apr;63(4):103817. doi: 10.1016/j.ejmg.2019.103817. Epub 2019 Nov 25. PubMed PMID: 31778854. 3. Gupta A, Zimmermann MT, Wang H, Broski SM, Sigafoos AN, Macklin SK, Urrutia RA, Clark KJ, Atwal PS, Pignolo RJ, Klee EW. Molecular characterization of known and novel ACVR1 variants in phenotypes of aberrant ossification. Am J Med Genet A. 2019 Sep;179(9):1764-1777. doi: 10.1002/ajmg.a.61274. Epub 2019 Jun 26. PubMed PMID: 31240838. 4. Gupta A, Juyal G, Sood A, Midha V, Yamazaki K, Vich Vila A, Esaki M, Matsui T, Takahashi A, Kubo M, Weersma RK, Thelma BK. A cross-ethnic survey of CFB and SLC44A4, Indian ulcerative colitis GWAS hits, underscores their potential role in disease susceptibility. Eur J Hum Genet. 2016 Jan;25(1):111-122. doi: 10.1038/ejhg.2016.131. Epub 2016 Oct 19. PubMed PMID: 27759029; PubMed Central PMCID: PMC5159766. 5. Gupta A, Thelma BK. Identification of critical variants within SLC44A4, an ulcerative colitis susceptibility gene identified in a GWAS in north Indians. Genes Immun. 2016 Mar;17(2):105-9. doi: 10.1038/gene.2015.53. Epub 2016 Jan 7. PubMed PMID: 26741288.